Abstract

Two new sterpurane sesquiterpenoids named sterpurol D (1) and sterpurol E (2), and one skeletally new sesquiterpene, cryptomaraone (3), bearing a 5,6-fused bicyclic ring system, along with five known ones, sterpurol A (4), sterpurol B (5), paneolilludinic Acid (6), murolane-2α, 9β-diol-3-ene (7) and (–)-10,11-dihydroxyfarnesol (8) were isolated from an endolichenic fungus Cryptomarasmius aucubae. The structures of the new compounds were elucidated by analysis of NMR spectroscopic spectra and HRESIMS data. The absolute configurations of 1 and 2 were established by spectroscopic data analysis and comparison of specific optical rotation, as well as the biosynthetic consideration. Additionally, compounds 1, 2, 4–6, and 8 showed significant nitric oxide (NO) production inhibition in Lipopolysaccharide (LPS)-induced BV-2 microglial cells with the IC50 values ranging from 9.06 to 14.81 μM.

Graphic Abstract

Details

Title
Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae
Author
Yi-Jie, Zhai 1 ; Jian-Nan, Li 1 ; Yu-Qi, Gao 1 ; Lin-Lin, Gao 1 ; Da-Cheng, Wang 1 ; Wen-Bo, Han 1   VIAFID ORCID Logo  ; Jin-Ming, Gao 1   VIAFID ORCID Logo 

1  Northwest A&F University, Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Yangling, People’s Republic of China (GRID:grid.144022.1) (ISNI:0000 0004 1760 4150) 
Pages
325-332
Publication year
2021
Publication date
Jun 2021
Publisher
Springer Nature B.V.
ISSN
21922195
e-ISSN
21922209
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s13659-021-00299-9
ProQuest document ID
2530598048
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.