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ABSTRACT:
Lozenges are one of the widely used solid, unit dosage form of medicament which are meant to be dissolved in mouth or pharynx. The benefits of the medicated lozenges is they increase the retention time of the dosage form in oral cavity which increases bioavailability, reduces gastric irritation and bypasses first pass metabolism. This dosage form can be adopted for local as well as systemic therapy and a wide range of active ingredient can be incorporated in them. The present review covers more or less all aspects associated with lozenge such as its manufacturing, classification, evaluation and its application Lozenges are one of the widely used solid, unit dosage form of medicament which are meant to be dissolved in mouth or pharynx. The benefits of the medicated lozenges is they increase the retention time of the dosage form in oral cavity which increases bioavailability, reduces gastric irritation and bypasses first pass metabolism. This dosage form can be adopted for local as well as systemic therapy and a wide range of active ingredient can be incorporated in them. The present review covers more or less all aspects associated with lozenge such as its manufacturing, classification, evaluation and its application.
KEYWORDS: Lozenges
INTRODUCTION:
Lozenges are the flavourized medicated dosage form intended to be sucked and held in the mouth or pharynx containing one or more medicaments usually in the sweetened base. Lozenges are intended to relieve oropharyngeal symptoms, which are commonly caused by local infections and also it provides systemic effect, the drug is well absorbed through the buccal linings or when it is swallowed. They are usually used for throat pain as well as irritation into throat extensively used to deliver the drug having topical anesthetic effect and also antibacterial effect[1].
Lozenges slowly releases the drug into buccal cavity for the purpose of yielding the required quantity of drug. Multiple number of drugs or ingredients can be incorporate into lozenges. These are OTC as well as prescription drug which totally depending on its content, it maximizes the local activity of drug and its absorption too, Widely they are used for treating the various conditions regarding to the mouth, tongue, throaf[1]
Definition:
Lozenges are solid dosage form containing the flavoring and sweetening agents that are...