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ABSTRACT:
The process of drug development and drug discovery is very challenging expensive and time consuming. It has been accelerated due to devlopment of computational tools and methods. In current situation lots of molecular docking software are available in the market, during lirerature survey it was found that Discovery Studio is suit of software for stimulating small molecule and macromolecule system. It is developed and distributed by Accelarys. It helps to Investigate and test hypothesis in silico prior it costly experimental implimentation thus reducing the time and expense involved in bringing products to market. it is developed and distributed by Dassault system BIOVIA (formerly Accelerys). During literature survey it was found that Discovery Studio software was efficiently guided to as author regarding mainly biological activities like anti-inflammatory activity, anti-tubercular activity, anti-bacterial activity, anti-viral activity, anti-diabetic activity and anti-oxidant activity.
KEYWORDS: Molecular docking, Drug discovery, Discovery studio.
INTRODUCTION:
Molecular docking is one of the most frequently used methods in structure based drug design, due to its ability to predict the binding- confirmation of the small molecule ligands to the appropriate target binding site. Discovery and development of a new drug is generally known as a very complex process which takes a lots of time and resources. So now a days computer aided drug design are used very widely to increase the efficiency of the discovery and development courses. CADD are evaluated as promising technique according to they need, in between all these structure - based drug design and ligand - based drug design. As very efficient and powerful technique in the drug Discovery and development. These both methods can be applied with molecular docking to the virtual screening for lead identification and optimization. Molecular docking is a key tool in structural molecular biology and computer assisted drug design.
Discovery studiosoftware is suit for stimulating small molecule and Macromolecule system. The product suite as astrong academic collaboration programme, supporting scientific research and makes use of a number of software algorithms developed originally in the scientific community, including CHARMM, MODELLER, DELPHI, ZDOCK, DMol3 and more [13].
REVIEW OF LITERATURE:
Qinggang Meng and et al used Discovery Studio Software check the Rizoma Atractylodis and Rhizoma Atractylodis Macroephalae herbal pairs against type 2 diabetes mellitus. the interaction between targets...