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Abstract
Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case–control study (2008–2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30–1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37–2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93–1.88). Frequent and long daytime naps increased the odds of colorectal (OR6–7 naps/week, ≥30 min: 1.32; 1.14–1.54) and gastric cancer (OR6–7 naps/week, ≥30 min: 1.56; 1.21–2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.
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1 Medical University of Vienna, Department of Epidemiology, Center of Public Health, Vienna, Austria (GRID:grid.22937.3d) (ISNI:0000 0000 9259 8492); ISGlobal, Barcelona, Spain (GRID:grid.434607.2) (ISNI:0000 0004 1763 3517)
2 ISGlobal, Barcelona, Spain (GRID:grid.434607.2) (ISNI:0000 0004 1763 3517); Universitat Pompeu Fabra (UPF), Barcelona, Spain (GRID:grid.5612.0) (ISNI:0000 0001 2172 2676); Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (GRID:grid.411142.3) (ISNI:0000 0004 1767 8811)
3 ISGlobal, Barcelona, Spain (GRID:grid.434607.2) (ISNI:0000 0004 1763 3517); Universitat Pompeu Fabra (UPF), Barcelona, Spain (GRID:grid.5612.0) (ISNI:0000 0001 2172 2676); Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); University of Ottawa, McLaughlin Centre for Population Health Risk Assessment, Ottawa, Canada (GRID:grid.28046.38) (ISNI:0000 0001 2182 2255)
4 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); University of León, Biomedicine Institute (IBIOMED), Leon, Spain (GRID:grid.4807.b) (ISNI:0000 0001 2187 3167)
5 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat, Unit of Molecular and Genetic Epidemiology in Infections and Cancer (UNIC-Molecular), Cancer Epidemiology Research Programme, Barcelona, Spain (GRID:grid.418284.3) (ISNI:0000 0004 0427 2257)
6 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); Department of Health of Madrid, Epidemiology Section, Public Health Division, Madrid, Spain (GRID:grid.466571.7)
7 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); University of Cantabria, Santander, Spain (GRID:grid.7821.c) (ISNI:0000 0004 1770 272X); IDIVAL, Santander, Spain (GRID:grid.484299.a)
8 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); Navarra Public Health Institute, Pamplona, Spain (GRID:grid.466571.7); Navarra Institute for Health Research, IdiSNA, Pamplona, Spain (GRID:grid.508840.1) (ISNI:0000 0004 7662 6114)
9 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); University of Granada, Department of Preventive Medicine and Public Health, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); Hospitales Universitarios de Granada/Universidad de Granada, Instituto de Investigacion Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994)
10 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); Public Health Division of Gipuzkoa, San Sebastian, Spain (GRID:grid.466571.7); Biodonostia Research Institute, San Sebastian, Spain (GRID:grid.432380.e)
11 FISABIO-Public Health, Cancer and Public Health Area, Valencia, Spain (GRID:grid.428862.2)
12 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); Universidad de Huelva, Centro de Investigación en Salud y Medio Ambiente (CYSMA), Huelva, Spain (GRID:grid.18803.32) (ISNI:0000 0004 1769 8134)
13 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); University of Oviedo, Health Research Institute of the Principality of Asturias, Oviedo, Spain (GRID:grid.10863.3c) (ISNI:0000 0001 2164 6351)
14 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); Murcia Regional Health Council, IMIB-Arrixaca, Department of Epidemiology, Murcia, Spain (GRID:grid.452553.0)
15 University of León, Biomedicine Institute (IBIOMED), Leon, Spain (GRID:grid.4807.b) (ISNI:0000 0001 2187 3167)
16 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); Carlos III Institute of Health, Cancer Epidemiology Unit of the National Center for Epidemiology, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); IIS Puerta de Hierro (IDIPHIM), Cancer Epidemiology Research Group, Oncology and Hematology Area, Madrid, Spain (GRID:grid.476442.7)
17 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); University of Cantabria, Santander, Spain (GRID:grid.7821.c) (ISNI:0000 0004 1770 272X)
18 Complejo Asistencial Universitario de León, Servicio de Oncología, Leon, Spain (GRID:grid.411969.2) (ISNI:0000 0000 9516 4411)
19 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); Carlos III Institute of Health, Cancer Epidemiology Unit of the National Center for Epidemiology, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427)
20 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); Catalan Institute of Oncology (ICO), Hospitalet de Llobregat, Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Barcelona, Spain (GRID:grid.418701.b) (ISNI:0000 0001 2097 8389); Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Colorectal Cancer Group, ONCOBELL Program, Barcelona, Spain (GRID:grid.418284.3) (ISNI:0000 0004 0427 2257); University of Barcelona, Department of Clinical Sciences, Faculty of Medicine, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247)