Abstract

Translate

Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease.

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Details

Title

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author

de Rojas, Itziar¹

; Moreno-Grau, Sonia¹; Tesi, Niccolo²; Grenier-Boley, Benjamin³; Andrade, Victor⁴; Jansen, Iris E.⁵; Pedersen, Nancy L.⁶; Stringa, Najada⁷

; Zettergren, Anna⁸

; Hernández, Isabel¹; Montrreal, Laura⁹; Antúnez, Carmen¹⁰; Antonell, Anna¹¹; Tankard, Rick M.¹²

; Bis, Joshua C.¹³; Sims, Rebecca¹⁴

; Bellenguez, Céline³

; Quintela, Inés¹⁵; González-Perez, Antonio¹⁶; Calero, Miguel¹⁷

; Franco-Macías, Emilio¹⁸; Macías, Juan¹⁹; Blesa, Rafael²⁰; Cervera-Carles, Laura²⁰

; Menéndez-González, Manuel²¹

; Frank-García, Ana²²; Royo, Jose Luís²³; Moreno, Fermin²⁴; Huerto Vilas, Raquel²⁵; Baquero, Miquel²⁶; Diez-Fairen, Mónica²⁷

; Lage, Carmen²⁸

; García-Madrona, Sebastián²⁹; García-González, Pablo⁹

; Alarcón-Martín, Emilio³⁰; Valero, Sergi¹; Sotolongo-Grau, Oscar⁹; Ullgren, Abbe³¹; Naj, Adam C.³²; Lemstra, Afina W.³³; Benaque, Alba⁹; Pérez-Cordón, Alba⁹

; Benussi, Alberto³⁴

; Rábano, Alberto³⁵; Padovani, Alessandro³⁴; Squassina, Alessio³⁶

; de Mendonça, Alexandre³⁷; Arias Pastor, Alfonso²⁵; Kok, Almar A. L.³⁸; Meggy, Alun³⁹; Pastor, Ana Belén⁴⁰

; Espinosa, Ana¹; Corma-Gómez, Anaïs¹⁹; Martín Montes, Angel⁴¹

; Sanabria, Ángela¹; DeStefano, Anita L.⁴²; Schneider, Anja⁴³; Haapasalo, Annakaisa⁴⁴

; Kinhult Ståhlbom, Anne³¹; Tybjærg-Hansen, Anne⁴⁵; Hartmann, Annette M.⁴⁶; Spottke, Annika⁴⁷; Corbatón-Anchuelo, Arturo⁴⁸; Rongve, Arvid⁴⁹

; Borroni, Barbara³⁴; Arosio, Beatrice⁵⁰; Nacmias, Benedetta⁵¹

; Nordestgaard, Børge G.⁵²

; Kunkle, Brian W.⁵³; Charbonnier, Camille⁵⁴; Abdelnour, Carla¹; Masullo, Carlo⁵⁵; Martínez Rodríguez, Carmen⁵⁶; Muñoz-Fernandez, Carmen⁵⁷; Dufouil, Carole⁵⁸; Graff, Caroline³¹; Ferreira, Catarina B.⁵⁹; Chillotti, Caterina⁶⁰; Reynolds, Chandra A.⁶¹

; Fenoglio, Chiara⁶²; Van Broeckhoven, Christine⁶³

; Clark, Christopher⁶⁴

; Pisanu, Claudia³⁶

; Satizabal, Claudia L.⁶⁵

; Holmes, Clive⁶⁶; Buiza-Rueda, Dolores⁶⁷; Aarsland, Dag⁶⁸

; Rujescu, Dan⁴⁶; Alcolea, Daniel²⁰

; Galimberti, Daniela⁶⁹

; Wallon, David⁷⁰

; Seripa, Davide⁷¹; Grünblatt, Edna⁷²

; Dardiotis, Efthimios⁷³; Düzel, Emrah⁷⁴; Scarpini, Elio⁶⁹; Conti, Elisa⁷⁵; Rubino, Elisa⁷⁶; Gelpi, Ellen⁷⁷; Rodriguez-Rodriguez, Eloy²⁸

; Duron, Emmanuelle⁷⁸; Boerwinkle, Eric⁷⁹; Ferri, Evelyn⁸⁰; Tagliavini, Fabrizio⁸¹; Küçükali, Fahri⁶³

; Pasquier, Florence⁸²

; Sanchez-Garcia, Florentino⁸³; Mangialasche, Francesca⁸⁴; Jessen, Frank⁸⁵; Nicolas, Gaël⁸⁶

; Selbæk, Geir⁸⁷

; Ortega, Gemma¹; Chêne, Geneviève⁵⁸; Hadjigeorgiou, Georgios⁸⁸; Rossi, Giacomina⁸¹; Spalletta, Gianfranco⁸⁹; Giaccone, Giorgio⁸¹; Grande, Giulia⁹⁰; Binetti, Giuliano⁹¹; Papenberg, Goran⁹⁰; Hampel, Harald⁹²; Bailly, Henri⁹³; Zetterberg, Henrik⁹⁴

; Soininen, Hilkka⁹⁵

; Karlsson, Ida K.⁹⁶; Alvarez, Ignacio⁹⁷

; Appollonio, Ildebrando⁹⁸; Giegling, Ina⁴⁶; Skoog, Ingmar⁸; Saltvedt, Ingvild⁹⁹

; Rainero, Innocenzo¹⁰⁰; Rosas Allende, Irene¹⁰¹; Hort, Jakub¹⁰²; Diehl-Schmid, Janine¹⁰³; Van Dongen, Jasper¹⁰⁴

; Vidal, Jean-Sebastien⁹³

; Lehtisalo, Jenni¹⁰⁵; Wiltfang, Jens¹⁰⁶; Thomassen, Jesper Qvist¹⁰⁷; Kornhuber, Johannes¹⁰⁸

; Haines, Jonathan L.¹⁰⁹

; Vogelgsang, Jonathan¹¹⁰

; Pineda, Juan A.¹⁹

; Fortea, Juan²⁰; Popp, Julius¹¹¹; Deckert, Jürgen¹¹²; Buerger, Katharina¹¹³; Morgan, Kevin¹¹⁴

; Fließbach, Klaus¹¹⁵; Sleegers, Kristel⁶³

; Molina-Porcel, Laura¹¹⁶; Kilander, Lena¹¹⁷; Weinhold, Leonie¹¹⁸; Farrer, Lindsay A.¹¹⁹

; Wang, Li-San¹²⁰; Kleineidam, Luca⁴; Farotti, Lucia¹²¹; Parnetti, Lucilla¹²¹; Tremolizzo, Lucio⁹⁸; Hausner, Lucrezia¹²²; Benussi, Luisa¹²³; Froelich, Lutz¹²²; Ikram, M. Arfan¹²⁴

; Deniz-Naranjo, M. Candida⁸³; Tsolaki, Magda¹²⁵

; Rosende-Roca, Maitée¹; Löwenmark, Malin¹²⁶; Hulsman, Marc¹²⁷; Spallazzi, Marco¹²⁸; Pericak-Vance, Margaret A.¹²⁹

; Esiri, Margaret¹³⁰; Bernal Sánchez-Arjona, María¹⁸; Dalmasso, Maria Carolina¹³¹; Martínez-Larrad, María Teresa⁴⁸; Arcaro, Marina¹³²; Nöthen, Markus M.¹³³; Fernández-Fuertes, Marta¹⁹; Dichgans, Martin¹³⁴

; Ingelsson, Martin¹³⁵; Herrmann, Martin J.¹¹²; Scherer, Martin¹³⁶; Vyhnalek, Martin¹⁰²; Kosmidis, Mary H.¹³⁷; Yannakoulia, Mary¹³⁸; Schmid, Matthias¹³⁹; Ewers, Michael¹¹³

; Heneka, Michael T.⁴³; Wagner, Michael⁴³

; Scamosci, Michela¹⁴⁰; Kivipelto, Miia¹⁴¹; Hiltunen, Mikko¹⁴²; Zulaica, Miren¹⁴³; Alegret, Montserrat¹; Fornage, Myriam¹⁴⁴; Roberto, Natalia⁹; van Schoor, Natasja M.⁷; Seidu, Nazib M.⁸; Banaj, Nerisa¹⁴⁵; Armstrong, Nicola J.¹²; Scarmeas, Nikolaos¹⁴⁶; Scherbaum, Norbert¹⁴⁷; Goldhardt, Oliver¹⁰³; Hanon, Oliver⁹³; Peters, Oliver¹⁴⁸; Skrobot, Olivia Anna¹⁴⁹; Quenez, Olivier⁵⁴

; Lerch, Ondrej¹⁰²; Bossù, Paola¹⁵⁰

; Caffarra, Paolo¹⁵¹; Dionigi Rossi, Paolo⁸⁰; Sakka, Paraskevi¹⁵²; Mecocci, Patrizia¹⁴⁰; Hoffmann, Per¹⁵³; Holmans, Peter A.¹⁴

; Fischer, Peter¹⁵⁴; Riederer, Peter¹⁵⁵; Yang, Qiong¹⁵⁶

; Marshall, Rachel¹⁴; Kalaria, Rajesh N.¹⁵⁷; Mayeux, Richard¹⁵⁸; Vandenberghe, Rik¹⁵⁹; Cecchetti, Roberta¹⁴⁰; Ghidoni, Roberta¹²³; Frikke-Schmidt, Ruth⁴⁵; Sorbi, Sandro⁵¹; Hägg, Sara⁶

; Engelborghs, Sebastiaan¹⁶⁰; Helisalmi, Seppo¹⁶¹; Botne Sando, Sigrid¹⁶²; Kern, Silke⁸; Archetti, Silvana¹⁶³; Boschi, Silvia¹⁰⁰; Fostinelli, Silvia¹²³; Gil, Silvia⁹; Mendoza, Silvia¹⁶⁴; Mead, Simon¹⁶⁵; Ciccone, Simona⁸⁰; Djurovic, Srdjan¹⁶⁶

; Heilmann-Heimbach, Stefanie¹³³; Riedel-Heller, Steffi¹⁶⁷; Kuulasmaa, Teemu¹⁴²; del Ser, Teodoro¹⁶⁸; Lebouvier, Thibaud⁸²; Polak, Thomas¹¹²; Ngandu, Tiia¹⁶⁹; Grimmer, Timo¹⁰³; Bessi, Valentina¹⁷⁰

; Escott-Price, Valentina¹⁷¹

; Giedraitis, Vilmantas¹⁷²

; Deramecourt, Vincent⁸²; Maier, Wolfgang⁴³; Jian, Xueqiu¹⁷³

; Pijnenburg, Yolande A. L.³³; Smith, A. David¹⁷⁴; Saenz, Aldo¹⁷⁵; Bizzarro, Alessandra¹⁷⁶; Lauria, Alessandra¹⁷⁶; Vacca, Alessandro¹⁰⁰; Solomon, Alina¹⁷⁷; Anastasiou, Anna¹²⁵; Richardson, Anna¹⁷⁸; Boland, Anne¹⁷⁹; Koivisto, Anne¹⁸⁰; Daniele, Antonio¹⁸¹; Greco, Antonio¹⁸²; Marianthi, Arnaoutoglou¹²⁵; McGuinness, Bernadette¹⁸³; Fin, Bertrand¹⁷⁹; Ferrari, Camilla¹⁸⁴; Custodero, Carlo¹⁸⁵; Ferrarese, Carlo⁹⁸; Ingino, Carlos¹⁸⁶; Mangone, Carlos¹⁸⁷; Reyes Toso, Carlos¹⁸⁸; Martínez, Carmen¹⁸⁹; Cuesta, Carolina¹⁹⁰; Muchnik, Carolina¹⁹¹; Joachim, Catharine¹⁹²; Ortiz, Cecilia¹⁹³; Besse, Céline¹⁷⁹; Johansson, Charlotte³¹; Zoia, Chiara Paola⁷⁵; Laske, Christoph¹⁹⁴; Anastasiou, Costas¹³⁸; Palacio, Dana Lis¹⁹⁵; Politis, Daniel G.¹⁹⁶; Janowitz, Daniel¹⁹⁷; Craig, David¹⁸³; Mann, David M.¹⁹⁸; Neary, David¹⁹⁹; Jürgen, Deckert¹¹²; Daian, Delphine¹⁷⁹; Belezhanska, Diyana²⁰⁰; Kohler, Eduardo²⁰¹; Castaño, Eduardo M.²⁰²; Koutsouraki, Effrosyni¹²⁵; Chipi, Elena¹²¹; De Roeck, Ellen²⁰³; Costantini, Emanuele¹⁸¹; Vardy, Emma R. L. C.²⁰⁴; Piras, Fabrizio¹⁴⁵; Roveta, Fausto¹⁰⁰; Piras, Federica¹⁴⁵; Prestia, Federico Ariel²⁰⁵; Assogna, Francesca¹⁴⁵; Salani, Francesca¹⁵⁰; Sala, Gessica⁷⁵; Lacidogna, Giordano¹⁸¹; Novack, Gisela²⁰⁶; Wilcock, Gordon²⁰⁷; Thonberg, Håkan³¹; Kölsch, Heike²⁰⁸; Weber, Heike¹¹²; Boecker, Henning²⁰⁹; Etchepareborda, Ignacio²¹⁰; Piaceri, Irene¹⁸⁴; Tuomilehto, Jaakko²¹¹; Lindström, Jaana²¹²; Laczo, Jan¹⁰²; Johnston, Janet¹⁸³; Deleuze, Jean-François¹⁷⁹; Harris, Jenny¹⁹⁹; Schott, Jonathan M.²¹³; Priller, Josef²¹⁴; Bacha, Juan Ignacio²¹⁵; Snowden, Julie¹⁷⁸; Lisso, Julieta²¹⁶; Mihova, Kalina Yonkova²¹⁷; Traykov, Latchezar²⁰⁰; Morelli, Laura²⁰²; Brusco, Luis Ignacio²¹⁸; Rainer, Malik¹⁹⁷; Takalo, Mari¹⁴²; Bjerke, Maria²¹⁹; Del Zompo, Maria²²⁰; Serpente, Maria⁶²; Sanchez Abalos, Mariana²²¹

; Rios, Mario²²²; Peltonen, Markku²¹²; Herrman, Martin J.¹¹²; Kohler, Matias²²³; Rojo, Matias²²⁴; Jones, Matthew²²⁵; Orsini, Michela¹⁸¹; Medel, Nancy²¹⁶; Olivar, Natividad²²⁶; Fox, Nick C.²²⁷; Salvadori, Nicola¹²¹; Hooper, Nigel M.²²⁸; Galeano, Pablo²²⁹; Solis, Patricia²¹⁶; Bastiani, Patrizia¹⁴⁰; Passmore, Peter¹⁸³; Heun, Reinhard²⁰⁸; Antikainen, Riitta²³⁰; Olaso, Robert¹⁷⁹; Perneczky, Robert²³¹; Germani, Sandra²³²; López-García, Sara²⁸; Love, Seth²³³; Mehrabian, Shima²⁰⁰; Bagnoli, Silvia¹⁸⁴; Kochen, Silvia²¹⁶; Andreoni, Simona⁷⁵; Teipel, Stefan²³⁴; Todd, Stephen¹⁸³; Pickering-Brown, Stuart¹⁹⁸; Natunen, Teemu¹⁴²; Tegos, Thomas¹²⁵; Laatikainen, Tiina²³⁵; Strandberg, Timo²³⁶; Polvikoski, Tuomo M.¹⁵⁷; Matoska, Vaclav²³⁷; Ciullo, Valentina¹⁴⁵; Cores, Valeria¹⁹⁶; Solfrizzi, Vincenzo¹⁸⁵; Lisetti, Viviana¹²¹; Sevillano, Zulma²¹⁶; Abdelnour, C.¹; Aguilera, N.⁹; Alarcon, E.³⁰; Alegret, M.¹; Benaque, A.⁹; Boada, M.¹; Buendia, M.⁹; Cañabate, P.¹; Carracedo, A.²³⁸; Corbatón-Anchuelo, A.³; de Rojas, I.⁹; Diego, S.⁹; Espinosa, A.¹; Gailhajenet, A.⁹; García-González, P.⁹; Gil, S.⁹; Guitart, M.⁹; González-Pérez, A.²³⁹; Hernández, I.¹; Ibarria, M.⁹; Lafuente, A.⁹; Macias, J.¹⁹; Maroñas, O.¹⁵; Martín, E.⁹; Martínez, M. T.²⁴⁰; Marquié, M.⁹; Mauleón, A.⁹; Montrreal, L.⁹; Moreno-Grau, S.¹; Moreno, M.⁹; Orellana, A.⁹; Ortega, G.¹; Pancho, A.⁹; Pelejá, E.⁹; Pérez-Cordon, A.⁹; Pineda, J. A.¹⁹; Preckler, S.⁹; Quintela, I.²³; Real, L. M.²⁴¹; Rosende-Roca, M.⁹; Ruiz, A.¹; Sáez, M. E.²⁴²; Sanabria, A.¹; Serrano-Rios, M.²⁴³; Sotolongo-Grau, O.⁹; Tárraga, L.¹; Valero, S.¹; Vargas, L.⁹; Adarmes-Gómez, A. D.²⁴⁴; Alarcón-Martín, E.³⁰; Alonso, M. D.²⁴⁵; Álvarez, I.²⁴⁶; Álvarez, V.¹⁰¹; Amer-Ferrer, G.²⁴⁷; Antequera, M.¹⁰; Antúnez, C.¹⁰; Baquero, M.²⁶; Bernal, M.¹⁸; Blesa, R.²⁰; Buiza-Rueda, D.²⁴⁴; Bullido, M. J.²⁴⁸; Burguera, J. A.²⁶; Calero, M.²⁴⁹; Carrillo, F.²⁴⁴; Carrión-Claro, M.²⁴⁴; Casajeros, M. J.²⁵⁰; Clarimón, J.²⁰; Cruz-Gamero, J. M.²³; de Pancorbo, M. M.²⁵¹; del Ser, T.²⁵²; Diez-Fairen, M.²⁵³; Escuela, R.²⁴⁴; Garrote-Espina, L.²⁴⁴; Fortea, J.²⁰; Franco-Macías, E.¹⁸; Frank-García, A.²⁵⁴; García-Alberca, J. M.²⁵⁵; Garcia Madrona, S.²⁹; Garcia-Ribas, G.²⁹; Gómez-Garre, P.²⁴⁴; Hevilla, S.²⁵⁶; Jesús, S.²⁴⁴; Labrador Espinosa, M. A.²⁴⁴; Lage, C.²⁸; Legaz, A.¹⁰; Lleó, A.²⁰; Lopez de Munain, A.²⁵⁷; López-García, S.²⁸; Macias-García, D.²⁴⁴; Manzanares, S.²⁵⁸; Marín, M.¹⁸; Marín-Muñoz, J.¹⁰; Marín, T.²⁵⁹; Martín Montes, A.²⁶⁰; Martínez, B.¹⁰; Martínez, C.¹⁸⁹; Martínez, V.¹⁰; Martínez-Lage Álvarez, P.²⁶¹; Medina, M.²⁶²; Mendioroz Iriarte, M.²⁶³; Menéndez-González, M.²⁶⁴; Mir, P.²⁴⁴; Molinuevo, J. L.²⁶⁵; Pastor, P.²⁶⁶; Pérez Tur, J.²⁶⁷; Periñán-Tocino, T.²⁴⁴; Pineda-Sanchez, R.²⁴⁴; Piñol-Ripoll, G.²⁶⁸; Rábano, A.³⁵; Real de Asúa, D.²⁶⁹; Rodrigo, S.¹⁸; Rodríguez-Rodríguez, E.²⁸; Royo, J. L.²³; Sanchez del Valle Díaz, R.¹¹; Sánchez-Juan, P.²⁸; Sastre, I.²⁷⁰; Vicente, M. P.¹⁰; Vigo-Ortega, R.²⁴⁴; Vivancos, L.¹⁰; Macleod, C.²⁷¹; McCracken, C.²⁷²; Brayne, Carol²⁷³; Bresner, Catherine¹⁴; Grozeva, Detelina¹⁴; Bellou, Eftychia¹⁴; Sommerville, Ewen W.¹⁴; Matthews, F.²⁷⁴; Leonenko, Ganna¹⁴; Menzies, Georgina³⁹; Windle, Gill²⁷¹; Harwood, Janet¹⁴; Phillips, Judith²⁷⁵; Bennett, K.²⁷⁶; Luckuck, Lauren¹⁴; Clare, Linda²⁷⁷; Woods, Robert²⁷⁸; Saad, Salha¹⁴; Burholt, Vanessa²⁷⁹; Kehoe, Patrick Gavin¹⁴⁹

; Garcia-Ribas, Guillermo²⁹; Sánchez-Juan, Pascual²⁸

; Pastor, Pau²⁸⁰

; Pérez-Tur, Jordi²⁶⁷

; Piñol-Ripoll, Gerard²⁵; Lopez de Munain, Adolfo²⁸¹

; García-Alberca, Jose María²⁸²

; Bullido, María J.²⁸³

; Álvarez, Victoria¹⁰¹; Lleó, Alberto²⁰

; Real, Luis M.²⁸⁴

; Mir, Pablo⁶⁷; Medina, Miguel²⁸⁵

; Scheltens, Philip³³; Holstege, Henne¹²⁷

; Marquié, Marta¹; Sáez, María Eugenia²⁴²

; Carracedo, Ángel²³⁸; Amouyel, Philippe³

; Schellenberg, Gerard D.¹²⁰; Williams, Julie²⁸⁶

; Seshadri, Sudha²⁸⁷

; van Duijn, Cornelia M.²⁸⁸

; Mather, Karen A.²⁸⁹

; Sánchez-Valle, Raquel¹¹; Serrano-Ríos, Manuel⁴⁸; Orellana, Adelina¹; Tárraga, Lluís¹; Blennow, Kaj²⁹⁰

; Huisman, Martijn²⁹¹; Andreassen, Ole A.²⁹²

; Posthuma, Danielle²⁹³; Clarimón, Jordi²⁰; Boada, Mercè¹

; van der Flier, Wiesje M.³³

; Ramirez, Alfredo²⁹⁴

; Lambert, Jean-Charles³

; van der Lee, Sven J.¹²⁷

; Ruiz, Agustín¹

¹ Universitat Internacional de Catalunya, Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain (GRID:grid.410675.1) (ISNI:0000 0001 2325 3084); National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427)
² Vrije Universiteit Amsterdam, Amsterdam UMC, Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227); Vrije Universiteit Amsterdam, Amsterdam UMC, Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227); Delft Univeristy of Technology, Delft Bioinformatics Lab, Delft, The Netherlands (GRID:grid.5292.c) (ISNI:0000 0001 2097 4740)
³ U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, Lille, France (GRID:grid.503422.2) (ISNI:0000 0001 2242 6780)
⁴ Medical Faculty, Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany (GRID:grid.10253.35) (ISNI:0000 0004 1936 9756); University Clinic Bonn, Department of Neurodegenerative diseases and Geriatric Psychiatry, Bonn, Germany (GRID:grid.15090.3d) (ISNI:0000 0000 8786 803X)
⁵ Vrije Universiteit Amsterdam, Amsterdam UMC, Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227); VU University, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227)
⁶ Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626)
⁷ Amsterdam Public Health Research Institute, Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam, The Netherlands (GRID:grid.16872.3a) (ISNI:0000 0004 0435 165X)
⁸ University of Gothenburg, Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), Gothenburg, Sweden (GRID:grid.8761.8) (ISNI:0000 0000 9919 9582)
⁹ Universitat Internacional de Catalunya, Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain (GRID:grid.410675.1) (ISNI:0000 0001 2325 3084)
¹⁰ Hospital Clínico Universitario Virgen de la Arrixaca, Unidad de Demencias, Murcia, Spain (GRID:grid.411372.2) (ISNI:0000 0001 0534 3000)
¹¹ University of Barcelona, Alzheimer’s disease and other cognitive disorders unit. Service of Neurology, Hospital Clínic of Barcelona. Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247)
¹² Murdoch University, Mathematics and Statistics, Perth, Australia (GRID:grid.1025.6) (ISNI:0000 0004 0436 6763)
¹³ University of Washington, Cardiovascular Health Research Unit, Department of Medicine, Seattle, USA (GRID:grid.34477.33) (ISNI:0000000122986657)
¹⁴ Cardiff University, Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff, UK (GRID:grid.5600.3) (ISNI:0000 0001 0807 5670)
¹⁵ Universidade de Santiago de Compostela, Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Santiago de Compostela, Spain (GRID:grid.11794.3a) (ISNI:0000000109410645)
¹⁶ CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain (GRID:grid.11794.3a)
¹⁷ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); UFIEC, Instituto de Salud Carlos III, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427)
¹⁸ Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Unidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain (GRID:grid.414816.e) (ISNI:0000 0004 1773 7922)
¹⁹ Hospital Universitario de Valme, Unidad Clínica de Enfermedades Infecciosas y Microbiología, Sevilla, Spain (GRID:grid.412800.f) (ISNI:0000 0004 1768 1690)
²⁰ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Universitat Autònoma de Barcelona, Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (GRID:grid.7080.f) (ISNI:0000 0001 2296 0625)
²¹ Hospital Universitario Central de Asturias, Servicio de Neurología, Oviedo, Spain (GRID:grid.411052.3) (ISNI:0000 0001 2176 9028); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (GRID:grid.511562.4); Universidad de Oviedo, Departamento de Medicina, Oviedo, Spain (GRID:grid.10863.3c) (ISNI:0000 0001 2164 6351)
²² National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Instituto de Investigación Sanitaria del Hospital Universitario La Paz, IdiPAZ, Department of Neurology, La Paz University Hospital, Madrid, Spain (GRID:grid.440081.9); Hospital La Paz Institute for Health Research, IdiPAZ, Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163); Universidad Autónoma de Madrid, Madrid, Spain (GRID:grid.5515.4) (ISNI:0000000119578126)
²³ University of Málaga, Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, Málaga, Spain (GRID:grid.10215.37) (ISNI:0000 0001 2298 7828)
²⁴ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Hospital Universitario Donostia, Department of Neurology, San Sebastian, Spain (GRID:grid.414651.3) (ISNI:0000 0000 9920 5292); Instituto Biodonostia, Neurosciences Area, San Sebastian, Spain (GRID:grid.432380.e)
²⁵ Hospital Universitari Santa Maria de Lleida, Unitat Trastorns Cognitius, Lleida, Spain (GRID:grid.490181.5); Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain (GRID:grid.420395.9) (ISNI:0000 0004 0425 020X)
²⁶ Hospital Universitari i Politècnic La Fe, Servei de Neurologia, Valencia, Spain (GRID:grid.84393.35) (ISNI:0000 0001 0360 9602)
²⁷ Fundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain (GRID:grid.84393.35); Hospital Universitari Mutua de Terrassa, Terrassa, Memory Disorders Unit, Department of Neurology, Barcelona, Spain (GRID:grid.414875.b) (ISNI:0000 0004 1794 4956)
²⁸ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Neurology Service, Santander, Spain (GRID:grid.411325.0) (ISNI:0000 0001 0627 4262)
²⁹ Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain (GRID:grid.411347.4) (ISNI:0000 0000 9248 5770)
³⁰ Universitat Internacional de Catalunya, Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain (GRID:grid.410675.1) (ISNI:0000 0001 2325 3084); University of Málaga, Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, Málaga, Spain (GRID:grid.10215.37) (ISNI:0000 0001 2298 7828)
³¹ Division of Neurogeriatrics, Karolinska Institutet, Center for Alzheimer Research, Department NVS, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626); Karolinska University Hospital-Solna, Unit for Hereditary Dementias, Theme Aging, Stockholm, Sweden (GRID:grid.24381.3c) (ISNI:0000 0000 9241 5705)
³² University of Pennsylvania Perelman School of Medicine, Department of Biostatistics, Epidemiology and Informatics, Philadelphia, USA (GRID:grid.25879.31) (ISNI:0000 0004 1936 8972); University of Pennsylvania Perelman School of Medicine, Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Philadelphia, USA (GRID:grid.25879.31) (ISNI:0000 0004 1936 8972)
³³ Vrije Universiteit Amsterdam, Amsterdam UMC, Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227)
³⁴ University of Brescia, Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, Brescia, Italy (GRID:grid.7637.5) (ISNI:0000000417571846)
³⁵ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); BT-CIEN, Madrid, Spain (GRID:grid.413448.e)
³⁶ University of Cagliari, Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, Cagliari, Italy (GRID:grid.7763.5) (ISNI:0000 0004 1755 3242)
³⁷ University of Lisbon, Faculty of Medicine, Lisbon, Portugal (GRID:grid.9983.b) (ISNI:0000 0001 2181 4263)
³⁸ Amsterdam Public Health Research Institute, Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam, The Netherlands (GRID:grid.16872.3a) (ISNI:0000 0004 0435 165X); Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands (GRID:grid.16872.3a) (ISNI:0000 0004 0435 165X)
³⁹ Cardiff University, UK Dementia Research Institute at Cardiff, Cardiff, UK (GRID:grid.5600.3) (ISNI:0000 0001 0807 5670)
⁴⁰ CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); BT-CIEN, Madrid, Spain (GRID:grid.413448.e)
⁴¹ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Hospital La Paz Institute for Health Research, IdiPAZ, Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163); La Paz University Hospital, Department of Neurology, Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163)
⁴² Boston University School of Medicine, Department of Neurology, Boston, USA (GRID:grid.189504.1) (ISNI:0000 0004 1936 7558); Boston University School of Public Health, Department of Biostatistics, Boston, USA (GRID:grid.189504.1) (ISNI:0000 0004 1936 7558)
⁴³ University Clinic Bonn, Department of Neurodegenerative diseases and Geriatric Psychiatry, Bonn, Germany (GRID:grid.15090.3d) (ISNI:0000 0000 8786 803X); German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426)
⁴⁴ University of Eastern Finland, A.I Virtanen Institute for Molecular Sciences, Kuopio, Finland (GRID:grid.9668.1) (ISNI:0000 0001 0726 2490)
⁴⁵ Rigshospitalet, Department of Clinical Biochemistry, Copenhagen, Denmark (GRID:grid.475435.4); University of Copenhagen, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen, Denmark (GRID:grid.5254.6) (ISNI:0000 0001 0674 042X)
⁴⁶ University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany (GRID:grid.9018.0) (ISNI:0000 0001 0679 2801)
⁴⁷ German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); University of Bonn, Department of Neurology, Bonn, Germany (GRID:grid.10388.32) (ISNI:0000 0001 2240 3300)
⁴⁸ Hospital Clínico San Carlos (IdISSC), Instituto de Investigación Sanitaria, Madrid, Spain (GRID:grid.411068.a) (ISNI:0000 0001 0671 5785); Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain (GRID:grid.430579.c) (ISNI:0000 0004 5930 4623)
⁴⁹ Helse Fonna, Department of Research and Innovation, Haugesund Hospital, Haugesund, Norway (GRID:grid.413782.b); University of Bergen, Institute of Clinical Medicine (K1), Bergen, Norway (GRID:grid.7914.b) (ISNI:0000 0004 1936 7443)
⁵⁰ University of Milan, Department of Clinical Sciences and Community Health, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822); IRCCS Ospedale Maggiore Policlinico, Geriatic Unit, Fondazione Cà Granda, Milan, Italy (GRID:grid.414818.0) (ISNI:0000 0004 1757 8749)
⁵¹ Drug Research and Child Health University of Florence, Department of Neuroscience, Psychology, Florence, Italy (GRID:grid.8404.8) (ISNI:0000 0004 1757 2304); IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy (GRID:grid.418563.d) (ISNI:0000 0001 1090 9021)
⁵² University of Copenhagen, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen, Denmark (GRID:grid.5254.6) (ISNI:0000 0001 0674 042X); Herlev Gentofte Hospital, Department of Clinical Biochemistry, Herlev, Denmark (GRID:grid.512920.d)
⁵³ University of Miami Miller School of Medicine, Dr. John T. Macdonald Foundation Department of Human Genetics, Miami, USA (GRID:grid.26790.3a) (ISNI:0000 0004 1936 8606); University of Miami Miller School of Medicine, John P. Hussman Institute for Human Genomics, Miami, USA (GRID:grid.26790.3a) (ISNI:0000 0004 1936 8606)
⁵⁴ FHU G4 Génomique, Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and CNR-MAJ, F-76000 Rouen, France (GRID:grid.41724.34) (ISNI:0000 0001 2296 5231)
⁵⁵ School of Medicine, Institute of Neurology, Catholic University of the Sacred Heart, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822)
⁵⁶ Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (GRID:grid.511562.4); Hospital de Cabueñes, Gijón, Spain (GRID:grid.414440.1) (ISNI:0000 0000 9314 4177)
⁵⁷ Hospital Universitario de Gran Canaria Dr.Negrín, Servicio de Neurología, Las Palmas, Spain (GRID:grid.411250.3) (ISNI:0000 0004 0399 7109)
⁵⁸ Univ Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, CIC 1401-EC, Bordeaux, France (GRID:grid.412041.2) (ISNI:0000 0001 2106 639X); CHU de Bordeaux, Pole de Santé Publique, Bordeaux, France (GRID:grid.42399.35) (ISNI:0000 0004 0593 7118)
⁵⁹ Universidade de Lisboa, Instituto de Medicina Molecular João lobo Antunes, Faculdade de Medicina, Lisboa, Portugal (GRID:grid.9983.b) (ISNI:0000 0001 2181 4263)
⁶⁰ University Hospital of Cagliari, Unit of Clinical Pharmacology, Cagliari, Italy (GRID:grid.9983.b)
⁶¹ University of California—Riverside, Department of Psychology, Riverside, USA (GRID:grid.266097.c) (ISNI:0000 0001 2222 1582)
⁶² Dino Ferrari Center, University of Milan, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822)
⁶³ VIB Center for Molecular Neurology, Antwerp, Belgium (GRID:grid.511528.a); Institute Born-Bunge, Laboratory of Neurogenetics, Antwerp, Belgium (GRID:grid.5284.b) (ISNI:0000 0001 0790 3681); University of Antwerp., Department of Biomedical Sciences, Antwerp, Belgium (GRID:grid.5284.b) (ISNI:0000 0001 0790 3681)
⁶⁴ University of Zürich, Insititute for Regenerative Medicine, Zürich, Switzerland (GRID:grid.7400.3) (ISNI:0000 0004 1937 0650)
⁶⁵ Boston University School of Medicine, Department of Neurology, Boston, USA (GRID:grid.189504.1) (ISNI:0000 0004 1936 7558); Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, San Antonio, USA (GRID:grid.189504.1); UT Health San Antonio, Department of Population Health Sciences, San Antonio, USA (GRID:grid.516130.0)
⁶⁶ University of Southampton, Division of Clinical Neurosciences, School of Medicine, Southampton, UK (GRID:grid.5491.9) (ISNI:0000 0004 1936 9297)
⁶⁷ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain (GRID:grid.414816.e) (ISNI:0000 0004 1773 7922)
⁶⁸ King’s College London, Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764); Stavanger University Hospital, Centre of Age-Related Medicine, Stavanger, Norway (GRID:grid.412835.9) (ISNI:0000 0004 0627 2891)
⁶⁹ Dino Ferrari Center, University of Milan, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822); Fondazione IRCCS Ca’ Granda, Ospedale Policlinico, Milan, Italy (GRID:grid.414818.0) (ISNI:0000 0004 1757 8749)
⁷⁰ Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Neurology and CNR-MAJ, FHU G4 Génomique, F-76000 Rouen, France (GRID:grid.41724.34) (ISNI:0000 0001 2296 5231)
⁷¹ Complex Structure of Geriatrics, Department of Medical Sciences Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy (GRID:grid.413503.0) (ISNI:0000 0004 1757 9135)
⁷² University of Zurich, Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich (PUK), Zurich, Switzerland (GRID:grid.7400.3) (ISNI:0000 0004 1937 0650); University of Zurich and ETH Zurich, Neuroscience Center Zurich, Zurich, Switzerland (GRID:grid.7400.3) (ISNI:0000 0004 1937 0650); University of Zurich, Zurich Center for Integrative Human Physiology, Zurich, Switzerland (GRID:grid.7400.3) (ISNI:0000 0004 1937 0650)
⁷³ University of Thessaly, School of Medicine, Larissa, Greece (GRID:grid.410558.d) (ISNI:0000 0001 0035 6670)
⁷⁴ German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); Otto-von-Guericke University, Institute of Cognitive Neurology and Dementia Research (IKND), Magdeburg, Germany (GRID:grid.5807.a) (ISNI:0000 0001 1018 4307)
⁷⁵ University of Milano-Bicocca and Milan Center for Neuroscience, School of Medicine and Surgery, Milan, Italy (GRID:grid.7563.7) (ISNI:0000 0001 2174 1754)
⁷⁶ AOU Città della Salute e della Scienza di Torino, Department of Neuroscience and Mental Health, Torino, Italy (GRID:grid.432329.d) (ISNI:0000 0004 1789 4477)
⁷⁷ Institut d’Investigacions Biomèdiques August Pi i Sunyer, Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Barcelona, Spain (GRID:grid.10403.36) (ISNI:0000000091771775); Medical University of Vienna, Division of Neuropathology and Neurochemistry, Department of Neurology, Vienna, Austria (GRID:grid.22937.3d) (ISNI:0000 0000 9259 8492)
⁷⁸ APHP, Hôpital Brousse, equipe INSERM 1178, MOODS, Villejuif, France (GRID:grid.50550.35) (ISNI:0000 0001 2175 4109); Le Kremlin-Bicêtre, Université Paris-Saclay, UVSQ, Inserm, CESP, Team MOODS, Paris, France (GRID:grid.413784.d) (ISNI:0000 0001 2181 7253); APHP, Hôpital Broca, Paris, France (GRID:grid.413802.c) (ISNI:0000 0001 0011 8533)
⁷⁹ University of Texas Health Science Center at Houston, School of Public Health, Human Genetics Center, Houston, USA (GRID:grid.267308.8) (ISNI:0000 0000 9206 2401); Baylor College of Medicine, Human Genome Sequencing Center, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X)
⁸⁰ IRCCS Ospedale Maggiore Policlinico, Geriatic Unit, Fondazione Cà Granda, Milan, Italy (GRID:grid.414818.0) (ISNI:0000 0004 1757 8749)
⁸¹ Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy (GRID:grid.417894.7) (ISNI:0000 0001 0707 5492)
⁸² Univ Lille, Inserm U1172, CHU, DISTAlz, LiCEND, Lille, France (GRID:grid.503422.2) (ISNI:0000 0001 2242 6780); CHU CNR-MAJ, Lille, France (GRID:grid.503422.2)
⁸³ Hospital Universitario de Gran Canaria Dr. Negrín, Servicio de Inmunología, Las Palmas de Gran Canaria, Spain (GRID:grid.411250.3) (ISNI:0000 0004 0399 7109)
⁸⁴ Karolinska Institutet, Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626)
⁸⁵ German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); Medical Faculty, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany (GRID:grid.10253.35) (ISNI:0000 0004 1936 9756); University of Cologne, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany (GRID:grid.6190.e) (ISNI:0000 0000 8580 3777)
⁸⁶ Hospital de Cabueñes, Gijón, Spain (GRID:grid.414440.1) (ISNI:0000 0000 9314 4177)
⁸⁷ Vestfold Hospital Trust, Norwegian National Advisory Unit on Ageing and Health, Tønsberg, Norway (GRID:grid.417292.b) (ISNI:0000 0004 0627 3659); Oslo University Hospital, Department of Geriatric Medicine, Oslo, Norway (GRID:grid.55325.34) (ISNI:0000 0004 0389 8485); University of Oslo, Institute of Clinical Medicine, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921)
⁸⁸ University of Cyprus, Department of Neurology, Medical School, Nicosia, Cyprus (GRID:grid.6603.3) (ISNI:0000000121167908)
⁸⁹ IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy (GRID:grid.417778.a) (ISNI:0000 0001 0692 3437); Baylor College of Medicine, Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X)
⁹⁰ Karolinska Institutet and Stockholm University, Aging Research Center, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden (GRID:grid.10548.38) (ISNI:0000 0004 1936 9377)
⁹¹ IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, MAC—Memory Clinic, Brescia, Italy (GRID:grid.419422.8); IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Molecular Markers Laboratory, Brescia, Italy (GRID:grid.419422.8)
⁹² Pitié-Salpêtrière Hospital, Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Paris, France (GRID:grid.411439.a) (ISNI:0000 0001 2150 9058)
⁹³ APHP, Hôpital Broca, Paris, France (GRID:grid.413802.c) (ISNI:0000 0001 0011 8533); Université Paris Descartes, EA 4468, Sorbonne Paris Cité, Paris, France (GRID:grid.508487.6) (ISNI:0000 0004 7885 7602)
⁹⁴ Sahlgrenska University Hospital, Clinical Neurochemistry Laboratory, Mölndal, Sweden (GRID:grid.1649.a) (ISNI:000000009445082X); Sahlgrenska Academy at the University of Gothenburg, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Gothenburg, Sweden (GRID:grid.8761.8) (ISNI:0000 0000 9919 9582); UCL Institute of Neurology, Department of Neurodegenerative Disease, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201); UK Dementia Research Institute at UCL, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
⁹⁵ University of Eastern Finland, Institute of Clinical Medicine Neurology, Kuopio, Finland (GRID:grid.9668.1) (ISNI:0000 0001 0726 2490); Kuopio University Hospital, Neurocenter, neurology, Kuopio, Finland (GRID:grid.410705.7) (ISNI:0000 0004 0628 207X)
⁹⁶ Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626); Jönköping University, Institute for Gerontology and Aging Research Network—Jönköping (ARN-J), School of Health and Welfare, Jönköping, Sweden (GRID:grid.118888.0) (ISNI:0000 0004 0414 7587)
⁹⁷ Fundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain (GRID:grid.118888.0); Hospital Universitari Mutua de Terrassa, Terrassa, Memory Disorders Unit, Department of Neurology, Barcelona, Spain (GRID:grid.414875.b) (ISNI:0000 0004 1794 4956)
⁹⁸ University of Milano-Bicocca and Milan Center for Neuroscience, School of Medicine and Surgery, Milan, Italy (GRID:grid.7563.7) (ISNI:0000 0001 2174 1754); Neurology Unit, ‘San Gerardo’ hospital, Monza, Italy (GRID:grid.415025.7) (ISNI:0000 0004 1756 8604)
⁹⁹ University Hospital of Trondheim, Department of Geriatrics, Clinic of Medicine, St Olavs Hospital, Trondheim, Norway (GRID:grid.52522.32) (ISNI:0000 0004 0627 3560); Norwegian University of Science and Technhology (NTNU), Department of Neuromedicine and Movement Science, Trondheim, Norway (GRID:grid.5947.f) (ISNI:0000 0001 1516 2393)
¹⁰⁰ University of Torino, Department of Neuroscience “Rita Levi Montalcini”, Torino, Italy (GRID:grid.7605.4) (ISNI:0000 0001 2336 6580)
¹⁰¹ Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (GRID:grid.511562.4); Hospital Universitario Central de Asturias, Laboratorio de Genética, Oviedo, Spain (GRID:grid.411052.3) (ISNI:0000 0001 2176 9028)
¹⁰² Charles University, Memory Clinic, Department of Neurology, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic (GRID:grid.4491.8) (ISNI:0000 0004 1937 116X); St. Anne’s University Hospital Brno, International Clinical Research Center, Brno, Czech Republic (GRID:grid.483343.b)
¹⁰³ Technical University of Munich, Department of Psychiatry and Psychotherapy, School of Medicine Klinikum rechts der Isar, Munich, Germany (GRID:grid.6936.a) (ISNI:0000000123222966)
¹⁰⁴ VIB Center for Molecular Neurology, Antwerp, Belgium (GRID:grid.511528.a); Institute Born-Bunge, Laboratory of Neurogenetics, Antwerp, Belgium (GRID:grid.5284.b) (ISNI:0000 0001 0790 3681)
¹⁰⁵ University of Eastern Finland, Institute of Clinical Medicine Neurology, Kuopio, Finland (GRID:grid.9668.1) (ISNI:0000 0001 0726 2490); Finnish Institute for Health and Welfare, Population Health Unit, Helsinki, Finland (GRID:grid.14758.3f) (ISNI:0000 0001 1013 0499)
¹⁰⁶ University Medical Center Goettingen, Department of Psychiatry and Psychotherapy, Goettingen, Germany (GRID:grid.411984.1) (ISNI:0000 0001 0482 5331); German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); University of Aveiro, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, Aveiro, Portugal (GRID:grid.7311.4) (ISNI:0000000123236065)
¹⁰⁷ Rigshospitalet, Department of Clinical Biochemistry, Copenhagen, Denmark (GRID:grid.475435.4)
¹⁰⁸ Friedrich-Alexander Universität Erlangen-Nürnberg, Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Erlangen, Germany (GRID:grid.5330.5) (ISNI:0000 0001 2107 3311)
¹⁰⁹ Case Western Reserve University, Department of Population & Quantitative Health Sciences, Cleveland, USA (GRID:grid.67105.35) (ISNI:0000 0001 2164 3847); Case Western Reserve University, Cleveland Institute for Computational Biology, Cleveland, USA (GRID:grid.67105.35) (ISNI:0000 0001 2164 3847)
¹¹⁰ University Medical Center Goettingen, Department of Psychiatry and Psychotherapy, Goettingen, Germany (GRID:grid.411984.1) (ISNI:0000 0001 0482 5331); Harvard Medical School, Translational Neuroscience Laboratory, McLean Hospital, Belmont, USA (GRID:grid.38142.3c) (ISNI:000000041936754X)
¹¹¹ University Hospital of Psychiatry Zürich, Department of Geriatric Psychiatry, Zürich, Switzerland (GRID:grid.412004.3) (ISNI:0000 0004 0478 9977); University of Zürich, Zürich, Switzerland (GRID:grid.7400.3) (ISNI:0000 0004 1937 0650); University Hospital of Lausanne, Old age Psychiatry, Lausanne, Switzerland (GRID:grid.8515.9) (ISNI:0000 0001 0423 4662)
¹¹² University Hospital, Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, Wuerzburg, Germany (GRID:grid.411760.5) (ISNI:0000 0001 1378 7891)
¹¹³ Ludwig-Maximilians-Universität LMU, Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X); German Center for Neurodegenerative Diseases (DZNE), Munich, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426)
¹¹⁴ University of Nottingham, Schools of Life Sciences and Medicine, Nottingham, UK (GRID:grid.4563.4) (ISNI:0000 0004 1936 8868)
¹¹⁵ University Clinic Bonn, Department of Neurodegenerative diseases and Geriatric Psychiatry, Bonn, Germany (GRID:grid.15090.3d) (ISNI:0000 0000 8786 803X)
¹¹⁶ University of Barcelona, Alzheimer’s disease and other cognitive disorders unit. Service of Neurology, Hospital Clínic of Barcelona. Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247); Institut d’Investigacions Biomèdiques August Pi i Sunyer, Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Barcelona, Spain (GRID:grid.10403.36) (ISNI:0000000091771775)
¹¹⁷ Department of Public Health and Caring Sciences/Geriatrics, Uppsala, Sweden (GRID:grid.10403.36)
¹¹⁸ University Hospital of Bonn, Institute of Medical Biometry, Informatics and Epidemiology, Bonn, Germany (GRID:grid.15090.3d) (ISNI:0000 0000 8786 803X)
¹¹⁹ Boston University Schools of Medicine and Public Health, Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Epidemiology, and Biostatistics, Boston, USA (GRID:grid.189504.1) (ISNI:0000 0004 1936 7558)
¹²⁰ University of Pennsylvania Perelman School of Medicine, Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Philadelphia, USA (GRID:grid.25879.31) (ISNI:0000 0004 1936 8972)
¹²¹ University of Perugia, Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, Perugia, Italy (GRID:grid.9027.c) (ISNI:0000 0004 1757 3630)
¹²² University of Heidelberg, Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg, Germany (GRID:grid.7700.0) (ISNI:0000 0001 2190 4373)
¹²³ IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Molecular Markers Laboratory, Brescia, Italy (GRID:grid.419422.8)
¹²⁴ Erasmus Medical Center, Department of Epidemiology, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:000000040459992X)
¹²⁵ 1st Department of Neurology Aristotle University of Thessaloniki, Thessaloniki, Greece (GRID:grid.4793.9) (ISNI:0000000109457005)
¹²⁶ Department of Public Health and Caring Sciences/Geriatrics, Uppsala, Sweden (GRID:grid.413448.e)
¹²⁷ Vrije Universiteit Amsterdam, Amsterdam UMC, Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227); Vrije Universiteit Amsterdam, Amsterdam UMC, Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227)
¹²⁸ Azienda Ospedaliero-Universitaria, Parma, Italy (GRID:grid.411482.a)
¹²⁹ University of Miami Miller School of Medicine, John P. Hussman Institute for Human Genomics, Miami, USA (GRID:grid.26790.3a) (ISNI:0000 0004 1936 8606)
¹³⁰ Nuffield Department of Clinical Neurosciences, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)
¹³¹ Medical Faculty, Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany (GRID:grid.10253.35) (ISNI:0000 0004 1936 9756)
¹³² Fondazione IRCCS Ca’ Granda, Ospedale Policlinico, Milan, Italy (GRID:grid.414818.0) (ISNI:0000 0004 1757 8749)
¹³³ School of Medicine & University Hospital Bonn, Institute of Human Genetics, University of Bonn, Bonn, Germany (GRID:grid.15090.3d) (ISNI:0000 0000 8786 803X)
¹³⁴ Ludwig-Maximilians-Universität LMU, Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X); German Center for Neurodegenerative Diseases (DZNE), Munich, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (GRID:grid.452617.3)
¹³⁵ Department of Public Health and Caring Sciences/Geriatrics, Uppsala, Sweden (GRID:grid.452617.3)
¹³⁶ University Medical Centre Hamburg-Eppendorf, Department of Primary Medical Care, Hamburg, Germany (GRID:grid.13648.38) (ISNI:0000 0001 2180 3484)
¹³⁷ Aristotle University of Thessaloniki, Laboratory of Cognitive Neuroscience, School of Psychology, Thessaloniki, Greece (GRID:grid.4793.9) (ISNI:0000000109457005)
¹³⁸ Harokopio University, Department of Nutrition and Dietetics, Athens, Greece (GRID:grid.15823.3d) (ISNI:0000 0004 0622 2843)
¹³⁹ German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); University Hospital of Bonn, Institute of Medical Biometry, Informatics and Epidemiology, Bonn, Germany (GRID:grid.15090.3d) (ISNI:0000 0000 8786 803X)
¹⁴⁰ University of Perugia, Institute of Gerontology and Geriatrics, Department of Medicine, Perugia, Italy (GRID:grid.9027.c) (ISNI:0000 0004 1757 3630)
¹⁴¹ Karolinska Institutet, Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626); University of Eastern Finland, Institute of Public Health and Clinical Nutrition, Kuopio, Finland (GRID:grid.9668.1) (ISNI:0000 0001 0726 2490); Imperial College London, Neuroepidemiology and Ageing Research Unit, School of Public Health, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111); Research & Development Unit, Stockholms Sjukhem, Stockholm, Sweden (GRID:grid.7445.2)
¹⁴² University of Eastern Finland, Institute of Biomedicine, Kuopio, Finland (GRID:grid.9668.1) (ISNI:0000 0001 0726 2490)
¹⁴³ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Instituto Biodonostia, Neurosciences Area, San Sebastian, Spain (GRID:grid.432380.e)
¹⁴⁴ University of Texas Health Sciences Center at Houston, Brown Foundation Institute of Molecular Medicine, Houston, USA (GRID:grid.267308.8) (ISNI:0000 0000 9206 2401)
¹⁴⁵ IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy (GRID:grid.417778.a) (ISNI:0000 0001 0692 3437)
¹⁴⁶ National and Kapodistrian University of Athens, Medical School, 1st Department of Neurology, Aiginition Hospital, Athens, Greece (GRID:grid.5216.0) (ISNI:0000 0001 2155 0800); Columbia University, Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Depatment of Neurology, New York, USA (GRID:grid.21729.3f) (ISNI:0000000419368729)
¹⁴⁷ University of Duisburg-Essen, LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, Essen, Germany (GRID:grid.5718.b) (ISNI:0000 0001 2187 5445)
¹⁴⁸ Charité-Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy and Experimental and Clinical Research Center (ECRC), Berlin, Germany (GRID:grid.6363.0) (ISNI:0000 0001 2218 4662); German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426)
¹⁴⁹ Southmead Hospital, Bristol Medical School (THS), University of Bristol, Bristol, UK (GRID:grid.416201.0) (ISNI:0000 0004 0417 1173)
¹⁵⁰ IRCCS Santa Lucia Foundation, Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, Rome, Italy (GRID:grid.417778.a) (ISNI:0000 0001 0692 3437)
¹⁵¹ University of Parma, Unit of Neuroscience, DIMEC, Parma, Italy (GRID:grid.10383.39) (ISNI:0000 0004 1758 0937)
¹⁵² Athens Association of Alzheimer’s disease and Related Disorders, Athens, Greece (GRID:grid.414818.0)
¹⁵³ School of Medicine & University Hospital Bonn, Institute of Human Genetics, University of Bonn, Bonn, Germany (GRID:grid.15090.3d) (ISNI:0000 0000 8786 803X); University Hospital Basel, Institute of Medical Genetics and Pathology, Basel, Switzerland (GRID:grid.410567.1)
¹⁵⁴ Social Medicine Center East- Donauspital, Department of Psychiatry, Vienna, Austria (GRID:grid.482677.8) (ISNI:0000 0000 9663 7831)
¹⁵⁵ University Hospital of Würzburg, Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, Würzburg, Germany (GRID:grid.411760.5) (ISNI:0000 0001 1378 7891)
¹⁵⁶ Boston University School of Public Health, Department of Biostatistics, Boston, USA (GRID:grid.189504.1) (ISNI:0000 0004 1936 7558)
¹⁵⁷ Newcastle University, Translational and Clincial Research Institute, Newcastle upon Tyne, UK (GRID:grid.1006.7) (ISNI:0000 0001 0462 7212); Campus for Ageing anf Vitality, Newcastle upon Tyne, UK (GRID:grid.1006.7)
¹⁵⁸ Columbia University, Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, New York, USA (GRID:grid.21729.3f) (ISNI:0000000419368729); Columbia University, Gertrude H. Sergievsky Center, New York, USA (GRID:grid.21729.3f) (ISNI:0000000419368729); Columbia University, Department of Neurology, New York, USA (GRID:grid.21729.3f) (ISNI:0000000419368729)
¹⁵⁹ University of Leuven, Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven, Belgium (GRID:grid.5596.f) (ISNI:0000 0001 0668 7884); University Hospitals Leuven, Neurology Department, Leuven, Belgium (GRID:grid.410569.f) (ISNI:0000 0004 0626 3338)
¹⁶⁰ Vrije Universiteit Brussel (VUB), Center for Neurosciences, Brussels, Belgium (GRID:grid.8767.e) (ISNI:0000 0001 2290 8069); University of Antwerp, Reference Center for Biological Markers of Dementia (BIODEM), Antwerp, Belgium (GRID:grid.5284.b) (ISNI:0000 0001 0790 3681); University of Antwerp, Institute Born-Bunge, Antwerp, Belgium (GRID:grid.5284.b) (ISNI:0000 0001 0790 3681); VUB University Hospital Brussels (UZ Brussel), Department of Neurology, Brussels, Belgium (GRID:grid.411326.3) (ISNI:0000 0004 0626 3362)
¹⁶¹ University of Eastern Finland, Institute of Clinical Medicine, Internal Medicine, Kuopio, Finland (GRID:grid.9668.1) (ISNI:0000 0001 0726 2490)
¹⁶² University Hospital of Trondheim, Department of Neurology and Clinical Neurophysiology, Trondheim, Norway (GRID:grid.52522.32) (ISNI:0000 0004 0627 3560); Norwegian University of Science and Technology, Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Trondheim, Norway (GRID:grid.5947.f) (ISNI:0000 0001 1516 2393)
¹⁶³ Brescia Hospital, Department of Laboratory Diagnostics, III Laboratory of Analysis, Brescia, Italy (GRID:grid.8761.8)
¹⁶⁴ Andalusian Institute for Neuroscience, Alzheimer Research Center & Memory Clinic, Málaga, Spain (GRID:grid.410675.1)
¹⁶⁵ Institute of Prion Diseases, MRC Prion Unit at UCL, London, UK (GRID:grid.421964.c) (ISNI:0000 0004 0606 3301)
¹⁶⁶ Oslo University Hospital, Department of Medical Genetics, Oslo, Norway (GRID:grid.55325.34) (ISNI:0000 0004 0389 8485); University of Bergen, NORMENT, Department of Clinical Science, Bergen, Norway (GRID:grid.7914.b) (ISNI:0000 0004 1936 7443)
¹⁶⁷ University of Leipzig, Institute of Social Medicine, Occupational Health and Public Health, Leipzig, Germany (GRID:grid.9647.c) (ISNI:0000 0004 7669 9786)
¹⁶⁸ Department of Neurology/CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427)
¹⁶⁹ Karolinska Institutet, Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626); Finnish Institute for Health and Welfare, Population Health Unit, Helsinki, Finland (GRID:grid.14758.3f) (ISNI:0000 0001 1013 0499)
¹⁷⁰ Drug Research and Child Health University of Florence, Department of Neuroscience, Psychology, Florence, Italy (GRID:grid.8404.8) (ISNI:0000 0004 1757 2304); Azienda Ospedaliero-Universitaria Careggi Largo Brambilla, Florence, Italy (GRID:grid.24704.35) (ISNI:0000 0004 1759 9494)
¹⁷¹ Cardiff University, Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff, UK (GRID:grid.5600.3) (ISNI:0000 0001 0807 5670); Cardiff University, UKDRI Cardiff, Cardiff, UK (GRID:grid.5600.3) (ISNI:0000 0001 0807 5670)
¹⁷² Department of Public Health and Caring Sciences/Geriatrics, Uppsala, Sweden (GRID:grid.5600.3)
¹⁷³ Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, San Antonio, USA (GRID:grid.424247.3)
¹⁷⁴ University of Oxford (OPTIMA), Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948); University of Oxford, OPTIMA, Department of Pharmacology, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)
¹⁷⁵ Salud Desarrollo Social y Deportes de la Pcia. de Mendoza, Dirección de Atención de Adultos Mayores del Min., Mendoza, Argentina (GRID:grid.4991.5)
¹⁷⁶ Geriatrics Unit Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy (GRID:grid.414603.4)
¹⁷⁷ Karolinska Institutet, Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626); University of Eastern Finland, Institute of Clinical Medicine Neurology, Kuopio, Finland (GRID:grid.9668.1) (ISNI:0000 0001 0726 2490)
¹⁷⁸ Salford Royal Hospital, Cerebral Function Unit, Greater Manchester Neurosciences Centre, Salford, UK (GRID:grid.415721.4) (ISNI:0000 0000 8535 2371); University of Manchester, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK (GRID:grid.5379.8) (ISNI:0000000121662407)
¹⁷⁹ Université Paris-Saclay, Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Evry, France (GRID:grid.460789.4) (ISNI:0000 0004 4910 6535)
¹⁸⁰ Kuopio University Hospital, Department of Neurology, Kuopio, Finland (GRID:grid.410705.7) (ISNI:0000 0004 0628 207X); University of Eastenr Finland, Insitute of Clinical Medicine-Neurology, Kuopio, Finland (GRID:grid.410705.7)
¹⁸¹ Fondazione Policlinico Universitario A. Gemelli IRCCS, Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy (GRID:grid.414603.4)
¹⁸² Fondazione IRCCS Casa Sollievo della Sofferenza, Research Laboratory, Complex Structure of Geriatrics, San Giovanni Rotondo, Foggia, Italy (GRID:grid.413503.0) (ISNI:0000 0004 1757 9135)
¹⁸³ Queen’s University Belfast, Centre for Public Health, School of Medicine, Belfast, UK (GRID:grid.4777.3) (ISNI:0000 0004 0374 7521)
¹⁸⁴ Drug Research and Child Health University of Florence, Department of Neuroscience, Psychology, Florence, Italy (GRID:grid.8404.8) (ISNI:0000 0004 1757 2304)
¹⁸⁵ University of Bari Aldo Moro, Clinica Medica “Frugoni” and Geriatric Medicine-Memory Unit, Bari, Italy (GRID:grid.7644.1) (ISNI:0000 0001 0120 3326)
¹⁸⁶ CENECON-FMED-UBA, Buenos Aires, Argentina (GRID:grid.415025.7); ENERI, Vienna, Austria (GRID:grid.415025.7)
¹⁸⁷ CENECON-FMED-UBA, Buenos Aires, Argentina (GRID:grid.415025.7); Htal Santojani, Buenos Aires, Argentina (GRID:grid.415025.7)
¹⁸⁸ CENECON-FMED-UBA, Buenos Aires, Argentina (GRID:grid.415025.7)
¹⁸⁹ Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (GRID:grid.511562.4); Hospital de Cabueñes, Servicio de Neurología, Gijón, Spain (GRID:grid.414440.1) (ISNI:0000 0000 9314 4177)
¹⁹⁰ UBA, Buenos Aires, Argentina (GRID:grid.7345.5) (ISNI:0000 0001 0056 1981); HIGA Eva Perón, Billinghurst, Argentina (GRID:grid.7345.5)
¹⁹¹ CENECON-FMED-UBA, Buenos Aires, Argentina (GRID:grid.7345.5)
¹⁹² University of Oxford, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)
¹⁹³ Neurología Clinica, Madrid, Spain (GRID:grid.4991.5)
¹⁹⁴ German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); University of Tübingen, Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, Tübingen, Germany (GRID:grid.10392.39) (ISNI:0000 0001 2190 1447)
¹⁹⁵ Hospital Dr. Lucio Molas, Santa Rosa, Argentina (GRID:grid.15823.3d); Fundacion Ayuda Enfermo Renal y Alta Complejidad (FERNAC), Santa Rosa, Argentina (GRID:grid.15823.3d)
¹⁹⁶ UBA, Buenos Aires, Argentina (GRID:grid.7345.5) (ISNI:0000 0001 0056 1981); HIGA Eva Perón, Billinghurst, Argentina (GRID:grid.7345.5); CONICET, Buenos Aires, Argentina (GRID:grid.423606.5) (ISNI:0000 0001 1945 2152)
¹⁹⁷ University Hospital, Ludwig-Maximilian University Munich, Institute for Stroke and Dementia Research (ISD), Munich, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X)
¹⁹⁸ Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, Manchester, UK (GRID:grid.5379.8) (ISNI:0000000121662407)
¹⁹⁹ Salford Royal Hospital, Cerebral Function Unit, Greater Manchester Neurosciences Centre, Salford, UK (GRID:grid.415721.4) (ISNI:0000 0000 8535 2371)
²⁰⁰ Medical University—Sofia, Clinic of Neurology UH ‘Alexandrovska’, Sofia, Bulgaria (GRID:grid.410563.5) (ISNI:0000 0004 0621 0092)
²⁰¹ Fundacion Sinapsis, Santa Rosa, Argentina (GRID:grid.410563.5)
²⁰² Laboratory of Brain Aging and Neurodegeneration- FIL, Buenos Aires, Argentina (GRID:grid.410563.5); IIBBA (CONICET), Buenos Aires, Argentina (GRID:grid.423606.5) (ISNI:0000 0001 1945 2152)
²⁰³ Vrije Universiteit Brussel (VUB), Center for Neurosciences, Brussels, Belgium (GRID:grid.8767.e) (ISNI:0000 0001 2290 8069)
²⁰⁴ Salford Royal NHS Foundation Trust, Salford, England (GRID:grid.412346.6) (ISNI:0000 0001 0237 2025)
²⁰⁵ HIGA Eva Perón, Billinghurst, Argentina (GRID:grid.417778.a); Laboratory of Brain Aging and Neurodegeneration- FIL, Buenos Aires, Argentina (GRID:grid.417778.a)
²⁰⁶ Laboratory of Brain Aging and Neurodegeneration- FIL, Buenos Aires, Argentina (GRID:grid.414603.4); IIBBA (CONICET), Buenos Aires, Argentina (GRID:grid.423606.5) (ISNI:0000 0001 1945 2152)
²⁰⁷ University of Oxford, Nuffield Department of Clinical Neurosciences, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)
²⁰⁸ University of Bonn, Department of Psychiatry, Bonn, Germany (GRID:grid.10388.32) (ISNI:0000 0001 2240 3300)
²⁰⁹ German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); University Hospital Bonn, Department of Radiology, Bonn, Germany (GRID:grid.15090.3d) (ISNI:0000 0000 8786 803X)
²¹⁰ Hospital Dr. Lucio Molas, Santa Rosa, Argentina (GRID:grid.15090.3d); Fundacion Ayuda Enfermo Renal y Alta Complejidad (FERNAC), Santa Rosa, Argentina (GRID:grid.15090.3d)
²¹¹ Finnish Institute for Health and Welfare, Population Health Unit, Helsinki, Finland (GRID:grid.14758.3f) (ISNI:0000 0001 1013 0499); University of Helsinki, Department of Public Health, Helsinki, Finland (GRID:grid.7737.4) (ISNI:0000 0004 0410 2071); National School of Public Health, Madrid, Spain (GRID:grid.512889.f) (ISNI:0000 0004 1768 0241); South Ostrobothnia Central Hospital, Seinäjoki, Finland (GRID:grid.415465.7) (ISNI:0000 0004 0391 502X)
²¹² Finnish Institute for Health and Welfare, Population Health Unit, Helsinki, Finland (GRID:grid.14758.3f) (ISNI:0000 0001 1013 0499)
²¹³ University College London, Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
²¹⁴ German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); Department of Neuropsychiatry, Charité, Berlin, Germany (GRID:grid.6363.0) (ISNI:0000 0001 2218 4662)
²¹⁵ Neurología Clinica, Madrid, Spain (GRID:grid.6363.0)
²¹⁶ ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET-Hospital El Cruce ‘Nestor Kirchner’-UNAJ, Buenos Aires, Argentina (GRID:grid.490137.8) (ISNI:0000 0004 0474 3784)
²¹⁷ Medical University of Sofia, Molecular Medicine Center, Department of Medical chemistry and biochemistry, Sofia, Bulgaria (GRID:grid.410563.5) (ISNI:0000 0004 0621 0092)
²¹⁸ CENECON-FMED-UBA, Buenos Aires, Argentina (GRID:grid.423606.5); ENERI, Vienna, Austria (GRID:grid.423606.5)
²¹⁹ Vrije Universiteit Brussel (VUB), Center for Neurosciences, Brussels, Belgium (GRID:grid.8767.e) (ISNI:0000 0001 2290 8069); UZ Brussel, Laboratory of Neurochemistry, Brussel, Belgium (GRID:grid.411326.3) (ISNI:0000 0004 0626 3362)
²²⁰ University of Cagliari, Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, Cagliari, Italy (GRID:grid.7763.5) (ISNI:0000 0004 1755 3242); Teaching Hospital of Cagliari, AOUCA, Unit of Clinical Pharmacology, Cagliari, Italy (GRID:grid.7763.5)
²²¹ Salud de la Pcia. de Jujuy, Programa del Adulto Mayor-Min, San Salvador de Jujuy, Argentina (GRID:grid.4708.b)
²²² Salud Desarrollo Social y Deportes de la Pcia. de Mendoza, Dirección de Atención de Adultos Mayores del Min., Mendoza, Argentina (GRID:grid.4708.b)
²²³ Hospital Dr. Lucio Molas, Santa Rosa, Argentina (GRID:grid.4793.9); Fundacion Sinapsis, Santa Rosa, Argentina (GRID:grid.4793.9)
²²⁴ CENECON-FMED-UBA, Buenos Aires, Argentina (GRID:grid.4793.9)
²²⁵ Salford Royal Hospital, Cerebral Function Unit, Greater Manchester Neurosciences Centre, Salford, UK (GRID:grid.415721.4) (ISNI:0000 0000 8535 2371); University of Manchester, Division of Neuroscience and Experimental Psychology, Manchester, UK (GRID:grid.5379.8) (ISNI:0000000121662407)
²²⁶ CENECON-FMED-UBA, Buenos Aires, Argentina (GRID:grid.490137.8)
²²⁷ University College London, Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201); University College London, UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
²²⁸ University of Manchester, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK (GRID:grid.5379.8) (ISNI:0000000121662407)
²²⁹ UBA, Buenos Aires, Argentina (GRID:grid.7345.5) (ISNI:0000 0001 0056 1981); Laboratory of Brain Aging and Neurodegeneration- FIL, Buenos Aires, Argentina (GRID:grid.7345.5); IIBBA (CONICET), Buenos Aires, Argentina (GRID:grid.423606.5) (ISNI:0000 0001 1945 2152)
²³⁰ University of Oulu, Center for Life Course Health Research, Oulu, Finland (GRID:grid.10858.34) (ISNI:0000 0001 0941 4873); Oulu University Hospital, Medical Research Center Oulu, Oulu, Finland (GRID:grid.412326.0) (ISNI:0000 0004 4685 4917); Oulu City Hospital, Oulu, Finland (GRID:grid.412326.0)
²³¹ Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (GRID:grid.452617.3); German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); University Hospital LMU Munich, Department of Psychiatry and Psychotherapy, Munich, Germany (GRID:grid.411095.8) (ISNI:0000 0004 0477 2585); Imperial College London, Ageing Epidemiology Research Unit (AGE), School of Public Health, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111)
²³² CENECON-FMED-UBA, Buenos Aires, Argentina (GRID:grid.7445.2)
²³³ Southmead Hospital, Bristol Medical School (THS), University of Bristol, Bristol, UK (GRID:grid.416201.0) (ISNI:0000 0004 0417 1173); Frenchay Hospital, University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Bristol, UK (GRID:grid.415059.c) (ISNI:0000 0004 0417 1114)
²³⁴ German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); Rostock University Medical Center, Department of Psychosomatic Medicine, Rostock, Germany (GRID:grid.413108.f) (ISNI:0000 0000 9737 0454)
²³⁵ University of Eastern Finland, Institute of Public Health and Clinical Nutrition, Kuopio, Finland (GRID:grid.9668.1) (ISNI:0000 0001 0726 2490); Finnish Institute for Health and Welfare, Helsinki, Finland (GRID:grid.14758.3f) (ISNI:0000 0001 1013 0499); Joint Municipal Authority for North Karelia Social and Health Services (Siun Sote), Joensuu, Finland (GRID:grid.14758.3f)
²³⁶ University of Oulu, Center for Life Course Health Research, Oulu, Finland (GRID:grid.10858.34) (ISNI:0000 0001 0941 4873); University of Helsinki, Helsinki University Hospital, Helsinki, Finland (GRID:grid.7737.4) (ISNI:0000 0004 0410 2071)
²³⁷ Na Homolce Hospital, Department of Clinical Biochemistry, Hematology and Immunology, Prague, Czech Republic (GRID:grid.414877.9) (ISNI:0000 0004 0609 2583)
²³⁸ Universidade de Santiago de Compostela, Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Santiago de Compostela, Spain (GRID:grid.11794.3a) (ISNI:0000000109410645); Fundación Pública Galega de Medicina Xenómica-CIBERER-IDIS, Santiago de Compostela, Spain (GRID:grid.443929.1) (ISNI:0000 0004 4688 8850)
²³⁹ CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain (GRID:grid.410675.1)
²⁴⁰ Helse Fonna, Department of Research and Innovation, Haugesund Hospital, Haugesund, Norway (GRID:grid.413782.b)
²⁴¹ University Clinic Bonn, Department of Neurodegenerative diseases and Geriatric Psychiatry, Bonn, Germany (GRID:grid.15090.3d) (ISNI:0000 0000 8786 803X); University of Málaga, Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, Málaga, Spain (GRID:grid.10215.37) (ISNI:0000 0001 2298 7828)
²⁴² CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain (GRID:grid.413448.e)
²⁴³ Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain (GRID:grid.430579.c) (ISNI:0000 0004 5930 4623)
²⁴⁴ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Unidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain (GRID:grid.414816.e) (ISNI:0000 0004 1773 7922)
²⁴⁵ Servei de Neurologia, Hospital Clínic Universitari de València, València, Spain (GRID:grid.5338.d) (ISNI:0000 0001 2173 938X)
²⁴⁶ Fundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain (GRID:grid.5338.d); Hospital Universitari Mutua de Terrassa, Terrassa, Memory Disorders Unit, Department of Neurology, Barcelona, Spain (GRID:grid.414875.b) (ISNI:0000 0004 1794 4956)
²⁴⁷ Hospital Universitario Son Espases, Department of Neurology, Palma, Spain (GRID:grid.411164.7) (ISNI:0000 0004 1796 5984)
²⁴⁸ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain (GRID:grid.465524.4); Instituto de Investigacion Sanitaria ‘Hospital la Paz’ (IdIPaz), Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163)
²⁴⁹ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain (GRID:grid.411347.4) (ISNI:0000 0000 9248 5770)
²⁵⁰ Hospital Universitario Ramón y Cajal, Madrid, Spain (GRID:grid.411347.4) (ISNI:0000 0000 9248 5770)
²⁵¹ Universidad del País Vasco UPV/EHU, BIOMICs, País Vasco, Centro de Investigación Lascaray, Leioa, Spain (GRID:grid.11480.3c) (ISNI:0000000121671098)
²⁵² Instituto de Investigacion Sanitaria ‘Hospital la Paz’ (IdIPaz), Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163)
²⁵³ Fundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain (GRID:grid.81821.32); Hospital Universitari Mutua de Terrassa, Terrassa, Memory Disorders Unit, Department of Neurology, Barcelona, Spain (GRID:grid.414875.b) (ISNI:0000 0004 1794 4956)
²⁵⁴ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Hospital La Paz Institute for Health Research, IdiPAZ, Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163); Instituto de Investigacion Sanitaria ‘Hospital la Paz’ (IdIPaz), Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163)
²⁵⁵ Andalusian Institute for Neuroscience, Alzheimer Research Center & Memory Clinic, Málaga, Spain (GRID:grid.81821.32)
²⁵⁶ Andalusian Institute for Neuroscience, Alzheimer Research Center & Memory Clinic, Málaga, Spain (GRID:grid.413448.e)
²⁵⁷ Hospital Universitario Donostia, Department of Neurology, San Sebastian, Spain (GRID:grid.414651.3) (ISNI:0000 0000 9920 5292); Instituto Biodonostia, Neurosciences Area, San Sebastian, Spain (GRID:grid.432380.e)
²⁵⁸ Hospital Universitario Son Espases, Department of Neurology, Palma, Spain (GRID:grid.411164.7) (ISNI:0000 0004 1796 5984); Fundación para la Formación e Investigación Sanitarias de la Región de Murcia, El Palmar, Spain (GRID:grid.424841.f)
²⁵⁹ Andalusian Institute for Neuroscience, Alzheimer Research Center & Memory Clinic, Málaga, Spain (GRID:grid.411372.2)
²⁶⁰ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Hospital La Paz Institute for Health Research, IdiPAZ, Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163); Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain (GRID:grid.465524.4)
²⁶¹ Centro de Investigacio´n y Terapias Avanzadas, Fundación CITA-alzheimer, San Sebastián, Spain (GRID:grid.428824.0)
²⁶² National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Instituto de Investigacion Sanitaria ‘Hospital la Paz’ (IdIPaz), Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163)
²⁶³ Navarrabiomed, Pamplona, Spain (GRID:grid.428855.6)
²⁶⁴ Hospital Universitario Central de Asturias, Servicio de Neurología, Oviedo, Spain (GRID:grid.411052.3) (ISNI:0000 0001 2176 9028); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (GRID:grid.511562.4)
²⁶⁵ Barcelona beta Brain Research Center–Fundació Pasqual Maragall, Barcelona, Spain (GRID:grid.430077.7)
²⁶⁶ Fundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain (GRID:grid.430077.7); Hospital Universitari Mutua de Terrassa, Terrassa, Memory Disorders Unit, Department of Neurology, Barcelona, Spain (GRID:grid.414875.b) (ISNI:0000 0004 1794 4956)
²⁶⁷ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Institut de Biomedicina de València-CSIC, Unitat de Genètica Molecular, Valencia, Spain (GRID:grid.413448.e); Instituto de Investigación Sanitaria La Fe, Unidad Mixta de Neurologia Genètica, Valencia, Spain (GRID:grid.84393.35) (ISNI:0000 0001 0360 9602)
²⁶⁸ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Hospital Universitari Santa Maria de Lleida, Unitat Trastorns Cognitius, Lleida, Spain (GRID:grid.490181.5); Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain (GRID:grid.420395.9) (ISNI:0000 0004 0425 020X)
²⁶⁹ Hospital Universitario La Princesa, Madrid, Spain (GRID:grid.411251.2) (ISNI:0000 0004 1767 647X)
²⁷⁰ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain (GRID:grid.465524.4)
²⁷¹ Bangor University, School of Health Sciences, Bangor, UK (GRID:grid.7362.0) (ISNI:0000000118820937)
²⁷² University of Liverpool, Institute of Psychology, Health and Society, Liverpool, England (GRID:grid.10025.36) (ISNI:0000 0004 1936 8470)
²⁷³ University of Cambridge, School of Clinical Medicine, Cambridge Institute of Public Health, Cambridge, England (GRID:grid.5335.0) (ISNI:0000000121885934)
²⁷⁴ University of Newcastle, Faculty of Medicine, Institute of Health and Society, Callaghan, Australia (GRID:grid.266842.c) (ISNI:0000 0000 8831 109X)
²⁷⁵ University of Stirling, Dementia Studies, Stirling, Scotland (GRID:grid.11918.30) (ISNI:0000 0001 2248 4331)
²⁷⁶ University of Liverpool, School of Psychology, Liverpool, England (GRID:grid.10025.36) (ISNI:0000 0004 1936 8470)
²⁷⁷ University of Exeter, School of Psychology, Centre for Research in Ageing and Cognitive Health (REACH), Exeter, England (GRID:grid.8391.3) (ISNI:0000 0004 1936 8024)
²⁷⁸ Bangor University, Dementia Services Development Centre, Wales, UK (GRID:grid.7362.0) (ISNI:0000000118820937)
²⁷⁹ Centre for Innovative Ageing, Swansea University, School of Human Sciences, Swansea, UK (GRID:grid.4827.9) (ISNI:0000 0001 0658 8800)
²⁸⁰ Fundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain (GRID:grid.411325.0); Hospital Universitari Mutua de Terrassa, Terrassa, Memory Disorders Unit, Department of Neurology, Barcelona, Spain (GRID:grid.414875.b) (ISNI:0000 0004 1794 4956)
²⁸¹ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Hospital Universitario Donostia, Department of Neurology, San Sebastian, Spain (GRID:grid.414651.3) (ISNI:0000 0000 9920 5292); Instituto Biodonostia, Neurosciences Area, San Sebastian, Spain (GRID:grid.432380.e); University of the Basque Country, Department of Neurosciences, Faculty of Medicine and Nursery, San Sebastián, Spain (GRID:grid.11480.3c) (ISNI:0000000121671098)
²⁸² National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Andalusian Institute for Neuroscience, Alzheimer Research Center & Memory Clinic, Málaga, Spain (GRID:grid.413448.e)
²⁸³ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Universidad Autónoma de Madrid, Madrid, Spain (GRID:grid.5515.4) (ISNI:0000000119578126); Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain (GRID:grid.465524.4); Instituto de Investigacion Sanitaria ‘Hospital la Paz’ (IdIPaz), Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163)
²⁸⁴ Hospital Universitario de Valme, Unidad Clínica de Enfermedades Infecciosas y Microbiología, Sevilla, Spain (GRID:grid.412800.f) (ISNI:0000 0004 1768 1690); Universidad de Málaga, Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina, Málaga, Spain (GRID:grid.10215.37) (ISNI:0000 0001 2298 7828)
²⁸⁵ National Institute of Health Carlos III, CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427)
²⁸⁶ Cardiff University, Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff, UK (GRID:grid.5600.3) (ISNI:0000 0001 0807 5670); Cardiff University, UK Dementia Research Institute at Cardiff, Cardiff, UK (GRID:grid.5600.3) (ISNI:0000 0001 0807 5670)
²⁸⁷ Boston University School of Medicine, Department of Neurology, Boston, USA (GRID:grid.189504.1) (ISNI:0000 0004 1936 7558); Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, San Antonio, USA (GRID:grid.189504.1); Framingham Heart Study, Framingham, USA (GRID:grid.510954.c) (ISNI:0000 0004 0444 3861)
²⁸⁸ Erasmus Medical Center, Department of Epidemiology, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:000000040459992X); University of Oxford, Nuffield Department of Population Health, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)
²⁸⁹ University of New South Wales, Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, Sydney, Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432); Neuroscience Research Australia, Sydney, Australia (GRID:grid.250407.4) (ISNI:0000 0000 8900 8842)
²⁹⁰ Sahlgrenska University Hospital, Clinical Neurochemistry Laboratory, Mölndal, Sweden (GRID:grid.1649.a) (ISNI:000000009445082X); Sahlgrenska Academy at the University of Gothenburg, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Gothenburg, Sweden (GRID:grid.8761.8) (ISNI:0000 0000 9919 9582)
²⁹¹ Amsterdam Public Health Research Institute, Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam, The Netherlands (GRID:grid.16872.3a) (ISNI:0000 0004 0435 165X); VU University, Department of Sociology, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227)
²⁹² University of Oslo, NORMENT Centre, Institute of Clinical Medicine, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921); Oslo University Hospital, Division of Mental Health and Addiction, Oslo, Norway (GRID:grid.55325.34) (ISNI:0000 0004 0389 8485)
²⁹³ VU University, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227)
²⁹⁴ Medical Faculty, Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany (GRID:grid.10253.35) (ISNI:0000 0004 1936 9756); University Clinic Bonn, Department of Neurodegenerative diseases and Geriatric Psychiatry, Bonn, Germany (GRID:grid.15090.3d) (ISNI:0000 0000 8786 803X); German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany (GRID:grid.424247.3) (ISNI:0000 0004 0438 0426); Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, Department of Psychiatry, San Antonio, USA (GRID:grid.424247.3)

Pages

3417

Publication year

2021

Publication date

2021

Publisher

Nature Publishing Group

e-ISSN

20411723

Source type

Scholarly Journal

Language of publication

English

DOI

https://doi.org/10.1038/s41467-021-22491-8

ProQuest document ID

2537861288

© The Author(s) 2021. corrected publication 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Jump to:

Abstract

Details

Suggested sources