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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: Vitamin D plays a pivotal role in calcium and phosphorus metabolism, also influencing bone tissue. Several studies have reported that vitamin D blood levels were significantly lower in people with obesity, probably due to its uptake by the adipose tissue. Clinical studies that investigated the changes of circulating levels of vitamin D following weight loss reported controversial data. A very low-calorie ketogenic diet is acknowledged as a reliable treatment to achieve a rapid weight loss. Therefore, we investigated the effect of weight loss, consequent to a very low-calorie ketogenic diet, on vitamin D blood concentrations. Methods: A cohort of 31 people with obesity underwent a very low-calorie ketogenic diet for 10–12 weeks. The serum concentrations of vitamin D, parathormone, calcium and phosphorous were measured before and after weight loss; they were compared to a control group of 20 non-obese, non-diabetic, age- and gender-matched persons. Results: Patients with obesity had a higher habitual intake of vitamin D than the control group (p < 0.05). However, the vitamin D blood levels of the obese group were significantly lower than those of the control group (p < 0.005) and they increased after weight loss (p < 0.001). At baseline, vitamin D blood concentrations of the persons with obesity were significantly correlated with both fat mass–kg (r = −0.40; p < 0.05) and body mass index (r = −0.47; p < 0.01). Following very low-calorie ketogenic diet, the change in vitamin D serum concentrations was correlated only with the change in fat mass–kg (r = −0.43; p < 0.01). Conclusion: This study confirmed that patients with obesity have lower vitamin D levels that normalize after significant weight loss, supporting the hypothesis that vitamin D is stored in the adipose tissue and released following weight loss.

Details

Title
Obesity and Circulating Levels of Vitamin D before and after Weight Loss Induced by a Very Low-Calorie Ketogenic Diet
Author
Buscemi, Silvio 1   VIAFID ORCID Logo  ; Buscemi, Carola 1 ; Corleo, Davide 1   VIAFID ORCID Logo  ; De Pergola, Giovanni 2 ; Caldarella, Rosalia 3 ; Meli, Francesco 3 ; Randazzo, Cristiana 1   VIAFID ORCID Logo  ; Milazzo, Salvatore 1   VIAFID ORCID Logo  ; Barile, Anna Maria 1 ; Rosafio, Giuseppe 1   VIAFID ORCID Logo  ; Settipani, Valentina 1 ; Gurrera, Sabina 1 ; Borzì, Antonio Maria 1 ; Ciaccio, Marcello 4   VIAFID ORCID Logo 

 Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, 90133 Palermo, Italy; [email protected] (C.B.); [email protected] (D.C.); [email protected] (R.C.); [email protected] (F.M.); [email protected] (C.R.); [email protected] (S.M.); [email protected] (A.M.B.); [email protected] (G.R.); [email protected] (V.S.); [email protected] (S.G.); [email protected] (A.M.B.); Unit of Clinical Nutrition, Policlinico University Hospital, 90127 Palermo, Italy 
 Department of Biomedical Science and Human Oncology, School of Medicine, Policlinico, University of Bari, 70124 Bari, Italy; [email protected] 
 Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, 90133 Palermo, Italy; [email protected] (C.B.); [email protected] (D.C.); [email protected] (R.C.); [email protected] (F.M.); [email protected] (C.R.); [email protected] (S.M.); [email protected] (A.M.B.); [email protected] (G.R.); [email protected] (V.S.); [email protected] (S.G.); [email protected] (A.M.B.); Unit of Laboratory Medicine, AOU Policlinico “P. Giaccone”, 90127 Palermo, Italy; [email protected] 
 Unit of Laboratory Medicine, AOU Policlinico “P. Giaccone”, 90127 Palermo, Italy; [email protected]; Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata (BIND), University of Palermo, 90133 Palermo, Italy 
First page
1829
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20726643
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2544924180
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.