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Abstract
Purpose: Peptides have proven to increase the length and thickness of the eyelash and stimulate the growth of new hair follicles. We evaluated the safety and efficacy of two different molecular-sizes peptides, the mitotic organelle (MO), and the nanoparticle (NOP) in enhancing eyelash and eyebrow growth.
Subjects and methods: A prospective randomized, doubleblinded, cohort, open 2-arm trial for 12 weeks to evaluate the efficacy and safety of weekly micro-needling and daily applied topical peptides on the eyelash and eyebrows. All subjects daily applied the designated peptide solution on their eyelids and eyebrows. They also attended a weekly micro-needling session to apply the peptide solution on the eyelash and eyebrow. The length of the eyelash was determined using an eyelash ruler while the overall eyelash appearance was assessed using the GEA scale. The eyebrows appearance was evaluated using digital photography and assessed by two independent dermatologists while individual eyebrow follicle thickness and the presence of new eyebrow hair follicles were evaluated using the Micro skin and hair diagnostic device (EW-EWB-1007-307, Germany).
Results: There was a 100% improvement in the GEA scale evaluation, moreover 33% (2/6) from the MO group and 17% (1/6) from the NOP group experienced a 2-grade improvement in the GEA scale. The mean change in the length of the eyelashes was 3.70 ± 1.4mm for the NOP group and 3.67 ± 1.4mm for the MO group. The eyebrow analyzer scans showed increased thickness in individual eyebrow and the presence of many new follicles for both groups. There were no serious adverse reactions or tolerability issues from both treatment groups.
Conclusion: Both peptide solutions were safe and efficient as a treatment to enhance eyelash and eyebrow appearance. Nanoparticles seem to bring the desired effects at a slightly faster rate, however, there was no statistically significant difference in the delivery of the final effect.
Keywords: Nanopeptides, Mitotic organelles, eyelash elongation, eyebrow thickness
Introduction
If the eyes are said to be the window of the soul, then the eyelashes and eyebrows must be the frame that makes it beautiful [1]. Besides the aesthetic and social value, these structures protect the eyes from trauma, irritants, ultraviolet rays and trigger the closing reflex [1]. Cosmetically enhancing the thickness, length, and shade of eyelashes and the eyebrows...