Effects of Neutrophil/Monocyte, Neutrophil/Lymphocyte, Neutrophil/Platelet Ratios and C-Reactive Protein Levels on the Mortality and Intensive Care Need of the Patients Diagnosed with Covid-19

Abstract

Objectives: The Covid-19 has been spreading rapidly worldwide. We investigated the effects of some laboratory parameters of patients diagnosed with Covid-19 on admission to the intensive care unit and mortality rate. We aim to be a reference to other countries with demonstrating the effect of laboratory parameters to prognosis and mortality as a center from Turkey. Methods: One hundred sixty patients diagnosed with Covid-19 that confirmed with PCR test included the study. The neutrophil/lymphocyte, neutrophil/monocyte neutrophil/platelet ratios, and C-reactive protein levels were evaluated. Patients were divided into 2 groups; who admitted to intensive care unit and who were treated in Covid-19 inpatient clinic without intensive care need. The groups were statistically compared. Mortality rates were examined to determine a cut-off value for each parameters. Results: These parameters and C-reactive protein levels of the Covid-19 patients were found to be statistically significant in both admission to the intensive care and mortality. The upper limits of these determined cut-off values are predicted to be critical for admission to intensive care. The cut-off values for NLR, NMR, NPR and CRP for mortality rate were 9.5, 3.7, 0.022, 79.2. Among these parameters, it was seen that the best determinant for mortality rate was CRP (cut-off=79.2). Conclusion: It was observed that NLR, NMR, NPR and CRP values were significant in determining the need for intensive care unit and mortality rate in patients diagnosed with Covid-19.