Abstract

The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.

Details

Title
SARS-CoV-2 and interferon blockade
Author
Diamond, Betty; Volpe, Bruce T  VIAFID ORCID Logo  ; VanPatten, Sonya; Yousef Al Abed
Pages
1-6
Section
Review
Publication year
2020
Publication date
2020
Publisher
Springer Nature B.V.
ISSN
10761551
e-ISSN
15283658
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s10020-020-00231-w
ProQuest document ID
2546934493
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.