Abstract

Objective: The COL6A1 is a gene encoding the alpha 1 polypeptide subunit of collagen 6 (COL6A1), an extracellular matrix protein subunit. Programmed cell death receptor-1 (PD-1) and its ligand, programmed cell death receptor ligand-1 (PD-L1) have been shown to have a prognostic significance in clear cell renal cell carcinomas (RCCs). In this study, we evaluated the expressions of COL6A1 and PD-1 in four different RCC subtypes.

Materials and methods: A total of 161 radical nephrectomy and nephron-sparing surgery cases with RCCs from five different health care centers were included in this study. Clinical data of the cases were taken from electronic records of the institutions. The pathological data were collected by an expert uropathologist and re-evaluated with slides obtained from paraffin blocks of the cases. The correlation of COL6A1 and PD-1 expression with sex, age, tumor type, lymphovascular invasion (LVI), World Health Organization/International Society of Urological Pathology (WHO/ISUP) grade, and tumor stage (pT) was analyzed with the Pearson chi-squared test.

Results: Patients with sarcomatoid RCC and clear cell RCC had significantly higher COL6A1 scores and intensities than in other types of RCC (p=0.004 and p=0.002, respectively). WHO/ISUP grade and, COL6A1 and PD-1 staining scores also showed positive correlation (r=0.230, p=0.004 and r=0.277, p=0.001, respectively for COL6A1 and r=0.191, p=0.018 and r=0.166, p=0.041, respectively for PD-1). The staining scores and intensities of COL6A1 and PD-1 were not different between the patients with positive and negative LVI (p>0.05).

Conclusion: In high-grade RCCs, we found the relationship between immunohistochemical staining scores of COL6A1 and PD-1 proteins and clinical, demographic, and histopathological parameters. Our results proved that COL6A1 and PD-1 are really promising proteins as prognostic parameters and for targeted immunotherapy.

Details

Title
The role of COL6A1and PD-1 expressions in renal cell carcinoma
Author
Karabulut, Yasemin Yuyucu; Köse, Emre Çağatay; Bozlu, Murat; Tuncel, Ferah; Yüksek, Gül Emek; Etit, Demet; Toru, Havva Serap; Akkaya, Bahar; Zeliha Esin Çelik; Öznur, Meltem; Temel, Gülhan Örekici; Akbay, Erdem
Pages
282-287
Section
UROONCOLOGY - Original Article
Publication year
2020
Publication date
Jul 2020
Publisher
Aves Yayincilik Ltd. STI.
ISSN
13005804
e-ISSN
13084631
Source type
Scholarly Journal
Language of publication
Turkish; English
ProQuest document ID
2547663248
Copyright
© 2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://turkishjournalofurology.com/en/copyright-1011