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© 2021. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction: Aplastic anemia is a rare and potentially life-threatening hematological disorder with incidence of 1.4 to 14 cases/million. It is associated with exposures to certain environmental chemicals, drugs and infections. The objective was to investigate the association of illness with family history of aplastic anemia, exposure to pesticides and chemicals.

Methodology: A hospital-based case–control study (191 cases, 696 controls) was conducted from 1st January 2015 to 31st December 2018 in Karachi, Sindh. Cases were patients with diagnosis of aplastic anemia confirmed with bone marrow biopsy. Controls neither had aplastic anemia nor other hematological chronic diseases. An in-person interview was conducted to collect demographic information, family history of aplastic anemia, and history of pesticide and chemical exposure. The adjusted odds ratios (aOR) with 95% confidence intervals (CI) were estimated via SPSS v22.

Results: A total of 191 confirmed aplastic anemia cases were selected. Mean age was 29 years (range: 4– 69) and predominantly there were males 129 (67.5%). The majority, 84 (44.0%), of the cases were aged 16– 30 years. In multivariate analysis models, the significant associations were observed between aplastic anemia with family history of aplastic anemia (aOR=13.3, 95% C.I 3.66– 48.50), exposure to pesticides (aOR=2.1, 95% C.I 1.23– 3.61) and chemicals (aOR=3.6, 95% C.I 2.06– 6.34).

Conclusion: This study observed a significant association of aplastic anemia with family history of aplastic anemia, exposure to pesticide and insecticide exposure. However, to establish this connection, further longitudinal studies are warranted.

Details

Title
Pesticides and Chemicals as Potential Risk Factors of Aplastic Anemia: A Case–Control Study Among a Pakistani Population
Author
Syed, Muhammad Asif; Aneela Atta Ur Rahman; Muhammad Ilyas Siddiqui; Ashique Ali Arain
Pages
469-475
Section
Original Research
Publication year
2021
Publication date
2021
Publisher
Taylor & Francis Ltd.
e-ISSN
1179-1349
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2552748641
Copyright
© 2021. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.