Abstract

Blood eosinophil count is a useful measure in asthma or COPD management. Recent epidemiological studies revealed that body mass index (BMI) is positively associated with eosinophil counts. However, few studies focused on the role of adiposity and fatty acid-related metabolites on eosinophil counts, including the effect of genetic polymorphism. In this community-based study involving 8265 participants (30–74 year old) from Nagahama city, we investigated the relationship between eosinophil counts and serum levels of fatty acid-related metabolites. The role of MDC1, a gene that is related to eosinophil counts in our previous study and encodes a protein that is thought to be involved in the repair of deoxyribonucleic acid damage, was also examined taking into account its interaction with adiposity. Serum levels of linoleic acid (LA) and β-hydroxybutyric acid (BHB) were negatively associated with eosinophil counts after adjustment with various confounders; however, there were positive interactions between serum LA and BMI and between serum BHB and BMI/body fat percentages in terms of eosinophil counts. In never-smokers, there was positive interaction for eosinophil counts between the CC genotype of MDC1 rs4713354 and BMI/body fat percentages. In conclusion, both serum LA and BHB have negative impacts on eosinophil counts, while adiposity shows robust positive effects on eosinophil counts, partly via genetic background in never-smokers.

Details

Title
Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study
Author
Nishi Kenta 1 ; Matsumoto Hisako 1 ; Tashima Noriyuki 1 ; Terada Satoru 1 ; Nomura Natsuko 1 ; Kogo Mariko 1 ; Morimoto Chie 1 ; Sunadome Hironobu 2 ; Nagasaki Tadao 2 ; Oguma Tsuyoshi 1 ; Nakatsuka Yoshinari 2 ; Murase Kimihiko 2 ; Kawaguchi Takahisa 3 ; Tabara Yasuharu 3 ; Sonomura Kazuhiro 3 ; Matsuda Fumihiko 3 ; Chin, Kazuo 2 ; Hirai Toyohiro 1 

 Kyoto University Graduate School of Medicine, Department of Respiratory Medicine, Kyoto, Japan (GRID:grid.258799.8) (ISNI:0000 0004 0372 2033) 
 Kyoto University Graduate School of Medicine, Department of Respiratory Care and Sleep Control Medicine, Kyoto, Japan (GRID:grid.258799.8) (ISNI:0000 0004 0372 2033) 
 Kyoto University Graduate School of Medicine, Center for Genomic Medicine, Kyoto, Japan (GRID:grid.258799.8) (ISNI:0000 0004 0372 2033) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2555779869
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.