It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
3, 8-dichloro-[1, 2, 4] triazolo [4, 3-a] pyrazine is an important intermediate for the synthesis of many small molecule anticancer drugs. It was synthesized from 2, 3-dichloropyrazine, N2H4• H2O (80%) and 2, 2, 2-trifluoroacetic anhydride through four steps including substitution, acylation, cyclization and chlorination reactions. The structure were confirmed by MS and 1H NMR. Furthermore, the synthetic method was optimized. The total yield of the four steps were 76.57%.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 School of Pharmacy, Jiangxi Science & Technology Normal University, Nan chang 330013, China