Abstract

The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.

Details

Title
Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
Author
Shi, Zhennan 1 ; Naowarojna, Nathchar 1   VIAFID ORCID Logo  ; Pan, Zijian 2   VIAFID ORCID Logo  ; Zou, Yilong 1   VIAFID ORCID Logo 

1  Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China (GRID:grid.494629.4) (ISNI:0000 0004 8008 9315); Westlake University, School of Life Sciences, Hangzhou, China (GRID:grid.494629.4) (ISNI:0000 0004 8008 9315); Institute of Biology, Westlake Institute of Advanced Studies, Hangzhou, China (GRID:grid.494629.4) 
2  Westlake University, School of Life Sciences, Hangzhou, China (GRID:grid.494629.4) (ISNI:0000 0004 8008 9315); Institute of Biology, Westlake Institute of Advanced Studies, Hangzhou, China (GRID:grid.494629.4) 
Pages
4792
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-021-25159-5
ProQuest document ID
2559540717
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.