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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Chemically modified nucleobases are thought to be important for therapeutic purposes as well as diagnosing genetic diseases and have been widely involved in research fields such as molecular biology and biochemical studies. Many artificially modified nucleobases, such as methyl, halogen, and aryl modifications of purines at the C8 position and pyrimidines at the C5 position, are widely studied for their biological functions. DNA containing these modified nucleobases can form non-canonical helical structures such as Z-DNA, G-quadruplex, i-motif, and triplex. This review summarizes the synthesis of chemically modified nucleotides: (i) methylation, bromination, and arylation of purine at the C8 position and (ii) methylation, bromination, and arylation of pyrimidine at the C5 position. Additionally, we introduce the non-canonical structures of nucleic acids containing these modifications.

Details

Title
Non-Canonical Helical Structure of Nucleic Acids Containing Base-Modified Nucleotides
Author
Balasubramaniyam, Thananjeyan 1 ; Oh, Kwnag-Im 1   VIAFID ORCID Logo  ; Ho-Seong, Jin 2 ; Hye-Bin Ahn 2 ; Kim, Byeong-Seon 3 ; Joon-Hwa, Lee 1   VIAFID ORCID Logo 

 Department of Chemistry, Gyeongsang National University, Jinju 52828, Gyeongnam, Korea; [email protected] (T.B.); [email protected] (K.-I.O.); [email protected] (H.-S.J.); [email protected] (H.-B.A.); The Research Institute of Natural Science, Gyeongsang National University, Jinju 52828, Gyeongnam, Korea 
 Department of Chemistry, Gyeongsang National University, Jinju 52828, Gyeongnam, Korea; [email protected] (T.B.); [email protected] (K.-I.O.); [email protected] (H.-S.J.); [email protected] (H.-B.A.) 
 The Research Institute of Natural Science, Gyeongsang National University, Jinju 52828, Gyeongnam, Korea; Department of Chemistry Education, Gyeongsang National University, Jinju 52828, Gyeongnam, Korea 
First page
9552
Publication year
2021
Publication date
2021
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2571238612
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.