It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Aneurysm wall enhancement (AWE) after the administration of contrast gadolinium is a potential biomarker of unstable intracranial aneurysms. While most studies determine AWE subjectively, this study comprehensively quantified AWE in 3D imaging using a semi-automated method. Thirty patients with 33 unruptured intracranial aneurysms prospectively underwent high-resolution imaging with 7T-MRI. The signal intensity (SI) of the aneurysm wall was mapped and normalized to the pituitary stalk (PS) and corpus callosum (CC). The CC proved to be a more reliable normalizing structure in detecting contrast enhancement (p < 0.0001). 3D-heatmaps and histogram analysis of AWE were used to generate the following metrics: specific aneurysm wall enhancement (SAWE), general aneurysm wall enhancement (GAWE) and focal aneurysm wall enhancement (FAWE). GAWE was more accurate in detecting known morphological determinants of aneurysm instability such as size ≥ 7 mm (p = 0.049), size ratio (p = 0.01) and aspect ratio (p = 0.002). SAWE and FAWE were aneurysm specific metrics used to characterize enhancement patterns within the aneurysm wall and the distribution of enhancement along the aneurysm. Blebs were easily identified on 3D-heatmaps and were more enhancing than aneurysm sacs (p = 0.0017). 3D-AWE mapping may be a powerful objective tool in characterizing different biological processes of the aneurysm wall.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 University of Iowa Carver College of Medicine, Department of Neurology, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
2 University of Iowa Carver College of Medicine, Department of Neurology, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294); University of Iowa Carver College of Medicine, Department of Neurosurgery, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
3 University of Iowa Carver College of Medicine, Department of Neurosurgery, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
4 University of Iowa, Roy J Carver Department of Biomedical Engineering, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
5 University of Iowa, Institute for Clinical and Translational Science, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
6 University of Iowa Carver College of Medicine, Department of Radiology, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
7 University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
8 University of Iowa Carver College of Medicine, Department of Neurology, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294); University of Iowa Carver College of Medicine, Department of Neurosurgery, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294); University of Iowa Carver College of Medicine, Department of Radiology, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)