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Abstract
Three - dimensional poly (e- caprolactone) (PCL) scaffolds as suitable biocompatible material for manufacturing tissue replacements are utilized for tissue engineering purposes. The porous structures are fabricated by rapid prototyping method (Bioscaffolder) based on hypodermic dispensing process. The consecution of experiments demonstrated the possibility on creation of surface micro formations, applying different laser fluences, at 1 kHz repetition rate for fixed time of exposure 1 sec at 800 nm central wavelength. The combination of both methods offers possibilities for successful production of 3D matrices with modified surfaces. The obtained results of laser - induced surface modifications of PCL demonstrate the potential of the method to microprocess this kind of material for possible applications in regenerative medicine.
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Details
1 Institute of Electronics, Bulgarian Academy of Sciences, 72, Tsarigradsko Chaussee Blvd., 1784 Sofia, Bulgaria
2 Institute of Solid State Physics, Bulgarian Academy of Sciences, 72, Tsarigradsko Chaussee Blvd., 1784 Sofia, Bulgaria
3 Biomaterials Group, Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, 141 Woloska Str., 02-507 Warsaw, Poland