Abstract

Circular RNAs (circRNAs) are known to act as key regulators in a variety of malignancies. However, the role of circRNAs in cervical cancer (CCa) remains largely unknown. Herein, we demonstrated that a circRNA derived from the TADA2A gene (hsa_circ_0043280) was significantly downregulated in CCa and that this reduction in expression was correlated with a poor prognosis. Furthermore, our results demonstrated that hsa_circ_0043280 functions as a tumor suppressor to inhibit tumor growth and metastasis in CCa. Mechanistically, hsa_circ_0043280 competitively sponges miR-203a-3p and prevents miR-203a-3p from reducing the levels of PAQR3. Collectively, our results demonstrate that hsa_circ_0043280 plays a pivotal role in the development and metastasis of CCa, thus suggesting that hsa_circ_0043280 has significant potential as a prognostic biomarker and a therapeutic target for CCa.

Details

Title
Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis
Author
Zhang, Chunyu 1 ; Liu, Pan 1 ; Huang, Jiaming 1 ; Liao Yuandong 1 ; Pan Chaoyun 2 ; Liu Junxiu 1 ; Du Qiqiao 1 ; Liu, Tianyu 1 ; Shang Chunliang 3 ; Ooi Shiyin 1 ; Chen, Run 1 ; Xia Meng 1 ; Jiang Hongye 1 ; Xu Manman 1 ; Zou Qiaojian 1 ; Zhou, Yijia 1 ; Huang, Hua 1 ; Pan Yuwen 1 ; Li, Yuan 1 ; Wang, Wei 1 ; Yao Shuzhong 1   VIAFID ORCID Logo 

1  Sun Yat-sen University, Department of Obstetrics and Gynecology, the First Affiliated Hospital, Guangzhou, China (GRID:grid.12981.33) (ISNI:0000 0001 2360 039X) 
2  Sun Yat-sen University, Department of Biochemistry and Molecular Biology, Zhongshan School of Medicine, Guangzhou, China (GRID:grid.12981.33) (ISNI:0000 0001 2360 039X) 
3  Peking University Third Hospital, Department of Obstetrics and Gynecology, Beijing, China (GRID:grid.411642.4) (ISNI:0000 0004 0605 3760) 
Publication year
2021
Publication date
Oct 2021
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41419-021-04193-7
ProQuest document ID
2577605084
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.