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Abstract
Aspirin-exacerbated respiratory disease (AERD) is characterized by immune cells dysfunction. This study aimed to investigate the molecular mechanisms involved in AERD pathogenesis. Relevant literatures were identified by a PubMed search (2005–2019) of english language papers using the terms “Aspirin-exacerbated respiratory disease”, “Allergic inflammation”, “molecular mechanism” and “mutation”. According to the significant role of inflammation in AERD development, ILC-2 is known as the most important cell in disease progression. ILC-2 produces cytokines that induce allergic reactions and also cause lipid mediators production, which activates mast cells and basophils, ultimately. Finally, Monoclonal antibody and Aspirin desensitization in patients can be a useful treatment strategy for prevention and treatment.
Details
; Najmaldin, Saki 2
; Maleknia Mohsen 3
; Moghaddasi Mana 4 ; Bordbar Armin 5
; Naghavi Maliheh 6
1 Ahvaz Jundishapur University of Medical Sciences, Atherosclerosis Research Center, Ahvaz, Iran (GRID:grid.411230.5) (ISNI:0000 0000 9296 6873)
2 Ahvaz Jundishapur University of Medical Sciences, Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz, Iran (GRID:grid.411230.5) (ISNI:0000 0000 9296 6873)
3 Ahvaz Jundishapur University of Medical Sciences, Student Research Committee, Ahvaz, Iran (GRID:grid.411230.5) (ISNI:0000 0000 9296 6873)
4 Payame Noor University (PUN), Department of Biology, Tehran, Iran (GRID:grid.412462.7) (ISNI:0000 0000 8810 3346)
5 Zanjan University of Medical Science, Department of Cardiology, Musavi Hospital, School of Medicine, Zanjan, Iran (GRID:grid.469309.1) (ISNI:0000 0004 0612 8427)
6 Zanjan University of Medical Science, Department of Pathology, Vali-E-Asr Hospital, School of Medicine, Zanjan, Iran (GRID:grid.469309.1) (ISNI:0000 0004 0612 8427)