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© 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The histological findings of gastritis. (a) A biopsy specimen shows epithalaxia at the surface and severe inflammatory cell infiltration in the lamina propria (HE, 100×). (b) Immunohistochemical staining of the biopsy specimen. IrAEs can be developed in many organs, including the gastrointestinal tract, endocrine organs, joints and skin, and nervous system. 1 Colitis is frequently noted, but gastritis is rarely reported. 2 The clinical symptoms suspecting ICI-related gastritis include nausea, vomiting, abdominal pain (epigastric pain), loss of appetite, and weight loss. Histologically, a combination of diffuse, moderate-to-severe active chronic gastritis with intra-epithelial lymphocytosis and increased apoptotic activity is the most helpful feature for diagnosing ICI-related gastritis. 3 The histological finding of exfoliated epithelial cells corresponds to the mucosal fragility and shallow erosion observed by EGD.

Details

Title
Immune checkpoint inhibitor‐related gastritis in a patient with metastatic melanoma
Author
Sugiyama, Yuya 1 ; Tanabe, Hiroki 1   VIAFID ORCID Logo  ; Fujiya, Mikihiro 1   VIAFID ORCID Logo 

 Division of Metabolism and Biosystemic Science, Gastroenterology, and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan 
Pages
1218-1219
Section
BRIEF REPORTS
Publication year
2021
Publication date
Oct 2021
Publisher
John Wiley & Sons, Inc.
e-ISSN
23979070
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2578064512
Copyright
© 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.