Abstract

Cancer stem cells (CSCs), which can self-renew and produce heterogeneous cancer cells, are the key factors during tumorigenesis. Transcription factors take essential effects on CSCs. However, the role of transcription factors in regulating the stemness of gastric cancer stem-like cells has not been well explored. In this investigation, it was found that transcription factor NME2 (NME/NM23 nucleoside diphosphate kinase 2) was upregulated in gastric cancer stem-like cells that sorted from the solid tumors of patients with gastric cancer and gastric cancer cell lines. NME2 could preserve the stemness of gastric cancer stem-like cells via suppressing their apoptosis. In vitro and in vivo data revealed that NME2 was crucial for maintaining the stemness of gastric cancer stem cells by enhancing the expression of anti-apoptosis genes. Consequently, our data contributed a new perspective to the relationship between transcription factor and the stemness maintenance of gastric cancer stem cells.

Details

Title
Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells
Author
Qi Yaxin 1 ; Wei, Jun 2 ; Zhang, Xiaobo 1   VIAFID ORCID Logo 

1  Zhejiang University, College of Life Sciences and Laboratory for Marine Biology and Biotechnology of Pilot National Laboratory for Marine Science and Technology (Qingdao), Hangzhou, People’s Republic of China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) 
2  Chengdu No.7 Ba Yi School, Chengdu, People’s Republic of China (GRID:grid.13402.34) 
Publication year
2021
Publication date
Oct 2021
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41419-021-04234-1
ProQuest document ID
2580376747
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.