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Abstract
Wound healing is a complicated multicellular process that involves several kinds of cells including macrophages, fibroblasts, endothelial cells, keratinocytes and platelets that are leading to their differentiation towards an anti-inflammatory response for producing several chemokines, cytokine and growth factors. In this study, electrospun nanofiber scaffold named (MNS) is composed of polyvinyl alcohol (PVA)/iota carrageenan (IC) and doped with partially reduced graphene oxide (prGO) that is successfully synthesized for wound healing and skin repair. The fabricated MNS was tested in case of infection and un-infection with E. coli and Staphylococcus and in both of the presence and in the absence of yeast as a natural nutritional supplement. Numerous biochemical parameters including total protein, albumin, urea and LDH, and hematological parameters were evaluated. Results revealed that the MNS was proved to be effective on most of the measured parameters and had exhibited efficient antibacterial inhibition activity. Whereas it can be used as an effective antimicrobial agent in wound healing, however, histopathological findings confirmed that the MNS caused re-epithelialization and the presence of yeast induced hair follicles growth and subsequently it may be used to hide formed head wound scar.
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1 City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, Alexandria, Egypt (GRID:grid.420020.4) (ISNI:0000 0004 0483 2576)
2 City of Scientific Research and Technological Applications (SRTA-City), Nucleic Acid Research Department, Genetic Engineering and Biotechnology Research Institute, Alexandria, Egypt (GRID:grid.420020.4) (ISNI:0000 0004 0483 2576)
3 City of Scientific Research and Technological Applications (SRTA-City), Pharmaceutical Bioproducts Research Department, Genetic Engineering and Biotechnology Research Institute, Alexandria, Egypt (GRID:grid.420020.4) (ISNI:0000 0004 0483 2576)
4 City of Scientific Research and Technological Applications (SRTA-City), Department of Medical Biotechnology, Genetic Engineering, and Biotechnology Research Institute, Alexandria, Egypt (GRID:grid.420020.4) (ISNI:0000 0004 0483 2576)
5 City of Scientific Research and Technological Applications (SRTA-City), Pharmaceutical and Fermentation Industries Development Centre, Alexandria, Egypt (GRID:grid.420020.4) (ISNI:0000 0004 0483 2576)
6 City of Scientific Research and Technological Applications (SRTA-City), Advanced Technology and New Materials Research Institute, Alexandria, Egypt (GRID:grid.420020.4) (ISNI:0000 0004 0483 2576)