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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Recent studies have suggested that gut–brain axis may be one of the mechanisms of major depression disorder (MDD). The current study aimed to investigate the effects of Lactobacillus plantarum PS128 (PS128) on psychophysiology in patients with MDD. We recruited 11 patients with MDD and gave them PS128 for 8 weeks. We compared depression symptoms, serum markers of inflammation and gut permeability, and gut microbiota before and after 8-week intervention and also explored the correlations among symptoms, biomarkers, and gut microbiota. After 8-week PS128 intervention, scores of Hamilton Depression Rating Scale-17 and Depression and Somatic symptoms Scale significantly decreased. Serum levels of high sensitivity c-reactive protein, interluekin-6, and tumor necrosis factor-α, zonulin and intestinal fatty acid binding protein, and the composition of gut microbiota did not significantly change after 8-week PS128 intervention. However, we found changes of some genera were correlated with changes of symptoms and biomarkers. In conclusion, this is an open trial with small sample size and has several limitations. The results need to be verified by randomized, double-blind, placebo-controlled trial with larger sample size.

Details

Title
Psychophysiological Effects of Lactobacillus plantarum PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial
Author
Hui-Mei, Chen 1 ; Kuo, Po-Hsiu 2   VIAFID ORCID Logo  ; Chia-Yueh Hsu 3 ; Yi-Hung, Chiu 4 ; Yen-Wenn Liu 5 ; Mong-Liang, Lu 3 ; Chun-Hsin, Chen 3 

 Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 100, Taiwan; [email protected] 
 Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 100, Taiwan; [email protected]; Department of Psychiatry, National Taiwan University Hospital, Taipei 100, Taiwan 
 Department of Psychiatry, Taipei Municipal Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan; [email protected] (C.-Y.H.); [email protected] (Y.-H.C.); [email protected] (M.-L.L.); Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan 
 Department of Psychiatry, Taipei Municipal Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan; [email protected] (C.-Y.H.); [email protected] (Y.-H.C.); [email protected] (M.-L.L.) 
 Institute of Biochemistry of Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan; [email protected] 
First page
3731
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20726643
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2602147113
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.