Abstract

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.

Details

Title
The JAK/STAT signaling pathway: from bench to clinic
Author
Hu, Xiaoyi 1   VIAFID ORCID Logo  ; li, Jing 2 ; Fu Maorong 2 ; Zhao, Xia 1 ; Wang, Wei 2   VIAFID ORCID Logo 

1  Sichuan University, and Collaborative Innovation Center for Biotherapy Chengdu, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan, P. R. China (GRID:grid.13291.38) (ISNI:0000 0001 0807 1581); West China Second Hospital, Sichuan University, Department of Gynecology and Obstetrics, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, P. R. China (GRID:grid.412901.f) (ISNI:0000 0004 1770 1022) 
2  Sichuan University, and Collaborative Innovation Center for Biotherapy Chengdu, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan, P. R. China (GRID:grid.13291.38) (ISNI:0000 0001 0807 1581) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
ISSN
20959907
e-ISSN
20593635
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41392-021-00791-1
ProQuest document ID
2602349277
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.