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© 2021 Kitagawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Syndecan-1 is found in the endothelial glycocalyx and is released into the bloodstream during stressed conditions, including severe diseases such as acute kidney injury, chronic kidney disease, and cardiovascular disease. This study investigated the prognostic value of serum syndecan-1 concentration in patients with heart failure upon admission. Serum syndecan-1 concentration was analyzed in 152 patients who were hospitalized for worsening heart failure from September 2017 to June 2018. The primary outcome of the study was readmission-free survival, defined as the time from the first admission to readmission for worsened heart failure or death from any cause, which was assessed at 30 months after discharge from the hospital. The secondary outcome of the study was survival time. Blood samples and echocardiogram data were analyzed. Univariate and multivariable time-dependent Cox regression analyses adjusted for age, creatinine levels, and use of antibiotics were conducted. The serum syndecan-1 concentration was significantly associated with readmission-free survival. Subsequently, the syndecan-1 concentration may have gradually decreased with treatment. The administration of human atrial natriuretic peptide and antibiotics may have modified the relationship between readmission-free survival and serum syndecan-1 concentration (p = 0.01 and 0.008, respectively). Serum syndecan-1 concentrations, which may indicate injury to the endothelial glycocalyx, predict readmission-free survival in patients with heart failure.

Details

Title
Serum syndecan-1 concentration in hospitalized patients with heart failure may predict readmission-free survival
Author
Kitagawa, Yuichiro; Kawamura, Itta; Suzuki, Keiko; Okada, Hideshi; Ishihara, Takuma; Tomita, Hiroyuki; Suzuki, Kodai; Takada, Chihiro; So Sampei; Kano, Soichiro; Kondo, Kohei; Asano, Hirotaka; Wakayama, Yugo; Kamidani, Ryo; Kawasaki, Yuki; Fukuda, Hirotsugu; Nishio, Ayane; Miyake, Takahito; Fukuta, Tetsuya; Yasuda, Ryu; Oiwa, Hideaki; Kakino, Yoshinori; Miyazaki, Nagisa; Watanabe, Takatomo; Yoshida, Takahiro; Doi, Tomoaki; Suzuki, Akio; Yoshida, Shozo; Matsuo, Hitoshi; Ogura, Shinji
First page
e0260350
Section
Research Article
Publication year
2021
Publication date
Dec 2021
Publisher
Public Library of Science
e-ISSN
19326203
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2608084561
Copyright
© 2021 Kitagawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.