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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

A study of the influence of chronic alcohol intoxication, constant illumination and their combined effects on the morphofunctional state of the rat liver and the circadian rhythms (CR) of the studied parameters of the organism was carried out. It was found that both alcohol and constant illumination caused significant changes in the structure of the liver, as well as in the circadian rhythmicity of micromorphometric parameters of hepatocytes, ALT, and total and direct bilirubin rhythms; however, the combined effects of ethanol and constant illumination had the most significant effect on the studied parameters of the organism. These two factors caused disturbances in the circadian rhythms of the micromorphometric parameters of hepatocytes, disruption of the circadian rhythms of total protein, albumin, AST, ALT, and direct and total bilirubin, as well as disturbances in the expression and rhythmicity of the studied clock genes against a background of the development of an inflammatory process in the liver.

Details

Title
Morphofunctional State and Circadian Rhythms of the Liver under the Influence of Chronic Alcohol Intoxication and Constant Lighting
Author
Kozlova, Maria A 1 ; Kirillov, Yuri A 1 ; Makartseva, Lyudmila A 1 ; Chernov, Igor 2   VIAFID ORCID Logo  ; Areshidze, David A 3 

 Laboratory of Cell Pathology, A.P. Avtsyn Research Institute of Human Morphology, 117218 Moscow, Russia; [email protected] (M.A.K.); [email protected] (Y.A.K.); [email protected] (L.A.M.) 
 Department of Pathological Anatomy, Tyumen State Medical University, 625023 Tyumen, Russia; [email protected] 
 Laboratory of Cell Pathology, A.P. Avtsyn Research Institute of Human Morphology, 117218 Moscow, Russia; [email protected] (M.A.K.); [email protected] (Y.A.K.); [email protected] (L.A.M.); Experimental Tumor Chemotherapy Group, Center for Screening and Preclinical Testing, Institute of Problems of Chemical Physics of the Russian Academy of Science, 142432 Chernogolovka, Russia 
First page
13007
Publication year
2021
Publication date
2021
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2608094944
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.