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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: Chronic renal failure is a chronic medical condition characterized by a progressive and irreversible loss of kidney function. Up to 50% of patients undergoing dialysis experience symptoms of depression and anxiety: what is the impact of individual factors and medical conditions on the mental health issue? The present study was carried out to investigate the individual factors (biomarkers and psychological dimensions) of end-stage renal disease patients dealing with dialysis, analyzing their predictor values for developing negative disease adaptations by an allostatic paradigm. Methods: We conducted an observational study on 35 patients affected by end-stage renal disease; biological and psychological markers have been detected. We conducted descriptive statistical analyses (t-tests) and performed a hierarchical regression analysis to investigate the relationship between pathological medical conditions and psychological dimensions. Results: The findings showed a positive correlation between creatinine levels and psychological distress as well as stress index. No significant effect of “time of dialysis”, “time from diagnosis”, “age” and “personality traits” was found. Conclusion: Our findings showed that personality traits did not represent a protective factor by moderating positive emotional adaptations; conversely, creatinine levels appeared predictive for negative emotional adaptations. High levels of creatinine were found to be positively associated with high stress levels as well psychological distress. According to the allostatic paradigm, end-stage renal disease patients could experience an allostatic load and more overload towards poor health outcomes; integrated biological and psychological measurements could prevent increased negative mental health through a patient-centered approach.

Details

Title
Chronic Kidney Disease and Its Relationship with Mental Health: Allostatic Load Perspective for Integrated Care
Author
Guerra, Federica 1   VIAFID ORCID Logo  ; Dina Di Giacomo 1   VIAFID ORCID Logo  ; Ranieri, Jessica 1   VIAFID ORCID Logo  ; Tunno, Marilena 2 ; Piscitani, Luca 2 ; Ferri, Claudio 3 

 Department Mesva, University of L’Aquila, 67100 L’Aquila, AQ, Italy; [email protected] (F.G.); [email protected] (D.D.G.); [email protected] (C.F.) 
 Dyalisis Division, San Salvatore Hospital of L’Aquila, 67100 L’Aquila, AQ, Italy; [email protected] (M.T.); [email protected] (L.P.) 
 Department Mesva, University of L’Aquila, 67100 L’Aquila, AQ, Italy; [email protected] (F.G.); [email protected] (D.D.G.); [email protected] (C.F.); Internal Medicine and Nephrology Division, San Salvatore Hospital of L’Aquila, 67100 L’Aquila, AQ, Italy 
First page
1367
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20754426
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2612800244
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.