Abstract/Details

Light, Fluidics and Their Applications in Global Sustainability and Health

Cao, Xiangkun (Elvis).   Cornell University ProQuest Dissertations Publishing,  2021. 28720290.

Abstract (summary)

The microscopic precision in simultaneous delivery of light and fluids by optofluidics offers great potential for global sustainability and health applications. Light drives photocatalytic reactions in a gas/liquid environment containing catalyst nanoparticles and reactants in global sustainability applications. The relevant efforts in this dissertation include: (1) a “shell-and-tube” glass waveguide-based photoreactor technology for converting CO2 to fuels, (2) a “gradient etching” approach to enable uniform light scattering of waveguides for enhanced photocatalytic degradation of methylene blue dyes, and (3) the optimization of both design and operating parameters of waveguide-based photoreactors via Multiphysics simulations. In global health applications, the fluidic environment involves various bodily fluids, such as serum, plasma, or human whole blood samples. Light irradiation by the optical reader excites the signals on test and control lines, and these line intensities are collected for later quantification of analyte concentrations. The health-related efforts in this dissertation include: (1) an iPad-based multiplexed lateral flow assay (LFA) system to differentially detect human malaria species with a single test line, (2) an optical reader-based multiplexed LFA system for differential diagnosis of malaria and typhoid infections, and (3) a fluorescence reader-based multiplexed LFA system for differentiating bacterial and viral infections.

Indexing (details)


Subject
Mechanical engineering;
Energy;
Biomedical engineering
Classification
0548: Mechanical engineering
0791: Energy
0541: Biomedical engineering
Identifier / keyword
Climate change; CO2 reduction; Global health; Global sustainability; Optofluidics; Point-of-care diagnostics
Title
Light, Fluidics and Their Applications in Global Sustainability and Health
Author
Cao, Xiangkun (Elvis)  VIAFID ORCID Logo 
Number of pages
205
Publication year
2021
Degree date
2021
School code
0058
Source
DAI-B 83/7(E), Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9798762181440
Advisor
Erickson, David
Committee member
Giannelis, Emmanuel; Mehta, Saurabh; Hanrath, Tobias
University/institution
Cornell University
Department
Mechanical Engineering
University location
United States -- New York
Degree
Ph.D.
Source type
Dissertation or Thesis
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
28720290
ProQuest document ID
2622245835
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
https://www.proquest.com/docview/2622245835