Abstract

Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis.

Details

Title
Advances in the pathogenesis of psoriasis: from keratinocyte perspective
Author
Zhou, Xue 1 ; Chen Youdong 1 ; Cui Lian 1 ; Shi, Yuling 1   VIAFID ORCID Logo  ; Guo Chunyuan 1   VIAFID ORCID Logo 

1  Tongji University School of Medicine, Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China (GRID:grid.24516.34) (ISNI:0000000123704535); Tongji University School of Medicine, Institute of Psoriasis, Shanghai, China (GRID:grid.24516.34) (ISNI:0000000123704535) 
Publication year
2022
Publication date
Jan 2022
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41419-022-04523-3
ProQuest document ID
2622381632
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.