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Abstract
Malaria remains a widespread public health problem in tropical and subtropical regions around the world, and there is still no vaccine available for full protection. In recent years, it has been observed that spores of Bacillus subtillis can act as a vaccine carrier and adjuvant, promoting an elevated humoral response after co-administration with antigens either coupled or integrated to their surface. In our study, B. subtillis spores from the KO7 strain were used to couple the recombinant CSP protein of P. falciparum (rPfCSP), and the nasal humoral-induced immune response in Balb/C mice was evaluated. Our results demonstrate that the spores coupled to rPfCSP increase the immunogenicity of the antigen, which induces high levels of serum IgG, and with balanced Th1/Th2 immune response, being detected antibodies in serum samples for 250 days. Therefore, the use of B. subtilis spores appears to be promising for use as an adjuvant in a vaccine formulation.
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1 Programa de Pós-Graduação Stricto Sensu em Biologia Celular e Molecular do Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, Brazil (GRID:grid.418068.3) (ISNI:0000 0001 0723 0931); Fiocruz Amazônia, Instituto Leônidas e Maria Deane, Manaus, Brazil (GRID:grid.418068.3)
2 Fiocruz Amazônia, Instituto Leônidas e Maria Deane, Manaus, Brazil (GRID:grid.418068.3); Universidade Federal do Amazonas (UFAM), Programa de Pós-Graduação em Biotecnologia, Instituto de Ciências Biológicas, Manaus, Brazil (GRID:grid.411181.c) (ISNI:0000 0001 2221 0517)
3 Fiocruz Amazônia, Instituto Leônidas e Maria Deane, Manaus, Brazil (GRID:grid.411181.c); Centro Universitário Fametro, Manaus, Brazil (GRID:grid.411181.c)
4 Fiocruz Amazônia, Instituto Leônidas e Maria Deane, Manaus, Brazil (GRID:grid.411181.c)
5 Fiocruz Amazônia, Instituto Leônidas e Maria Deane, Manaus, Brazil (GRID:grid.411181.c); Universidade Federal do Amazonas (UFAM), Programa de Pós-Graduação em Biotecnologia, Instituto de Ciências Biológicas, Manaus, Brazil (GRID:grid.411181.c) (ISNI:0000 0001 2221 0517)
6 Fiocruz Amazônia, Instituto Leônidas e Maria Deane, Manaus, Brazil (GRID:grid.411181.c); Programa de Pós-Graduação Stricto Sensu em Biologia Parasitária do Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, Brazil (GRID:grid.418068.3) (ISNI:0000 0001 0723 0931)
7 Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas, HEMOAM, Manaus, Brazil (GRID:grid.512139.d) (ISNI:0000 0004 0635 1549)
8 Universidade Federal Do Amazonas (UFAM), Programa de Pós-Graduação em Imunologia Básica e Aplicada, Instituto de Ciências Biológicas, Manaus, Brazil (GRID:grid.411181.c) (ISNI:0000 0001 2221 0517); Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas, HEMOAM, Manaus, Brazil (GRID:grid.512139.d) (ISNI:0000 0004 0635 1549); Universidade do Estado do Amazonas (UEA), Programa de Pós-Graduação Stricto Sensu em Ciências Aplicadas à Hematologia PPGH, Manaus, Brazil (GRID:grid.412290.c) (ISNI:0000 0000 8024 0602)
9 Universidade Federal do Amazonas (UFAM), Centro de Apoio Multidisciplinar (CAM), Manaus, Brazil (GRID:grid.411181.c) (ISNI:0000 0001 2221 0517)
10 Universidade Federal do Amazonas (UFAM), Instituto de Ciências Biológicas (ICB), Manaus, Brazil (GRID:grid.411181.c) (ISNI:0000 0001 2221 0517)
11 Instituto Nacional de Pesquisa da Amazônia – INPA, Manuas, Brazil (GRID:grid.419220.c) (ISNI:0000 0004 0427 0577)
12 Fiocruz Amazônia, Instituto Leônidas e Maria Deane, Manaus, Brazil (GRID:grid.419220.c); Programa de Pós-Graduação Stricto Sensu em Biologia Parasitária do Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, Brazil (GRID:grid.418068.3) (ISNI:0000 0001 0723 0931)
13 Federico II University, Department of Biology, Naples, Italy (GRID:grid.4691.a) (ISNI:0000 0001 0790 385X)
14 Programa de Pós-Graduação Stricto Sensu em Biologia Celular e Molecular do Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro, Brazil (GRID:grid.418068.3) (ISNI:0000 0001 0723 0931); Fiocruz Amazônia, Instituto Leônidas e Maria Deane, Manaus, Brazil (GRID:grid.418068.3); Universidade Federal do Amazonas (UFAM), Programa de Pós-Graduação em Biotecnologia, Instituto de Ciências Biológicas, Manaus, Brazil (GRID:grid.411181.c) (ISNI:0000 0001 2221 0517); Universidade Federal Do Amazonas (UFAM), Programa de Pós-Graduação em Imunologia Básica e Aplicada, Instituto de Ciências Biológicas, Manaus, Brazil (GRID:grid.411181.c) (ISNI:0000 0001 2221 0517)