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Abstract
Social animals actively engage in contact with conspecifics and experience stress upon isolation. However, the neural mechanisms coordinating the sensing and seeking of social contacts are unclear. Here we report that amylin-calcitonin receptor (Calcr) signaling in the medial preoptic area (MPOA) mediates affiliative social contacts among adult female mice. Isolation of females from free social interactions first induces active contact-seeking, then depressive-like behavior, concurrent with a loss of Amylin mRNA expression in the MPOA. Reunion with peers induces physical contacts, activates both amylin- and Calcr-expressing neurons, and leads to a recovery of Amylin mRNA expression. Chemogenetic activation of amylin neurons increases and molecular knockdown of either amylin or Calcr attenuates contact-seeking behavior, respectively. Our data provide evidence in support of a previously postulated origin of social affiliation in mammals.
The mechanisms coordinating the sensing and seeking of social contacts are unclear. Here, the authors show that amylin-calcitonin receptor signalling in the media preoptic area mediates affiliative social behaviors in female mice.
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1 RIKEN Center for Brain Science, Laboratory for Affiliative Social Behavior, Saitama, Japan (GRID:grid.474690.8)
2 RIKEN Center for Brain Science, Laboratory for Affiliative Social Behavior, Saitama, Japan (GRID:grid.474690.8); Nippon Veterinary and Life Science University, Musashino, Department of Animal Science, Faculty of Applied Life Science, Tokyo, Japan (GRID:grid.412202.7) (ISNI:0000 0001 1088 7061)
3 RIKEN Center for Brain Science, Laboratory for Circuit and Behavioral Physiology, Saitama, Japan (GRID:grid.474690.8)
4 RIKEN Center for Brain Science, Laboratory for Behavioral Genetics, Saitama, Japan (GRID:grid.474690.8)
5 Nippon Veterinary and Life Science University, Musashino, Department of Animal Science, Faculty of Applied Life Science, Tokyo, Japan (GRID:grid.412202.7) (ISNI:0000 0001 1088 7061)