Abstract

The effect of apical lymph node (APN) metastasis on the prognosis of colon cancer is unknown. The present study investigated the impact of APN metastasis on the prognosis of the patients with high-risk stage III colon cancer. This retrospective multi-institutional study included patients with pathological high-risk stage III colon cancer who underwent surgery between April 2009 and December 2014. Clinicopathological factors were examined by univariate and multivariate analyses to clarify independent risk factors for overall survival (OS) and relapse-free survival (RFS). A total of 185 patients were collected. The 5-year OS rates of patients with and without APN metastasis were 35.0% and 72.1%, respectively (p = 0.0014). The 5-year RFS rates of patients with and without APN metastasis was 16.2% and 57.2%, respectively (p = 0.0002). The rate of distant metastasis in patients with APN metastasis was significantly higher than that in patients without APN metastasis (68.8% vs. 36.7%, p = 0.012). The univariate analysis revealed that the differentiation, lymph node ratio, and APN metastasis were significantly associated with 5-year OS, and the preoperative CEA and CA19-9 levels and APN metastasis were significantly associated with 5-year RFS. The multivariate analysis showed that APN metastasis was an independent risk factor for 5-year OS and RFS. APN metastasis may be independently associated with the prognosis of patients with high-risk Stage III colon cancer.

Details

Title
The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer
Author
Ishii Kenichi 1   VIAFID ORCID Logo  ; Watanabe, Jun 1   VIAFID ORCID Logo  ; Goto Kouki 1 ; Suwa Yusuke 1 ; Nakagawa Kazuya 2 ; Suwa Hirokazu 3 ; Ozawa Mayumi 2 ; Ishibe Atsushi 2 ; Kunisaki Chikara 1 ; Endo Itaru 2 

1  Yokohama City University Medical Center, Department of Surgery, Gastroenterological Center, Yokohama, Japan (GRID:grid.413045.7) (ISNI:0000 0004 0467 212X) 
2  Yokohama City University Graduate School of Medicine, Department of Gastroenterological Surgery, Yokohama, Japan (GRID:grid.268441.d) (ISNI:0000 0001 1033 6139) 
3  Yokosuka Kyosai Hospital, Department of Surgery, Yokosuka, Japan (GRID:grid.417369.e) (ISNI:0000 0004 0641 0318) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-022-06054-5
ProQuest document ID
2626565307
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.