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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: Oral squamous cell carcinoma (OSCC) is a common cancer with high morbidity and mortality. Alterations of antitumor immune responses are involved in the development of this malignancy, and investigation of immune changes in the peripheral blood of OSCC patients has aroused the interest of researchers. Methods: In our study, we assessed the proportions of CD3+ total T lymphocytes, CD3+CD4+ helper T lymphocytes, CD3+CD8+ suppressor/cytotoxic T lymphocytes, CD3−CD19+ total B lymphocytes, and CD3−CD16+CD56+ NK cells in the peripheral blood of OSCC patients. Results: The data obtained both pre- and post-therapy showed a similar level of total CD3+ T lymphocytes in OSCC patients and control subjects, pinpointing the stability of this immune parameter. On the other hand, pre-therapeutic data showed a lower proportion of helper T lymphocytes (CD4+), a significantly higher level of cytotoxic/suppressive T lymphocytes (CD8+), and a much lower CD4+ T lymphocyte/CD8+ T lymphocyte ratio compared to control subjects. Conversely, evaluation of circulating NK (CD16+) cells showed a markedly higher pre-therapeutic level compared to the control group. Conclusions: Our results related to immune changes in the peripheral blood add new information to this complex universe of connections between immuno-inflammatory processes and carcinogenesis.

Details

Title
Persistent Changes of Peripheral Blood Lymphocyte Subsets in Patients with Oral Squamous Cell Carcinoma
Author
Caruntu, Ana 1   VIAFID ORCID Logo  ; Moraru, Liliana 1 ; Surcel, Mihaela 2   VIAFID ORCID Logo  ; Munteanu, Adriana 3   VIAFID ORCID Logo  ; Costache, Daniel Octavian 4   VIAFID ORCID Logo  ; Tanase, Cristiana 5   VIAFID ORCID Logo  ; Constantin, Carolina 6   VIAFID ORCID Logo  ; Scheau, Cristian 7   VIAFID ORCID Logo  ; Neagu, Monica 8   VIAFID ORCID Logo  ; Caruntu, Constantin 9   VIAFID ORCID Logo 

 Department of Oral and Maxillofacial Surgery, The “Carol Davila” Central Military Emergency Hospital, 010825 Bucharest, Romania; [email protected] (A.C.); [email protected] (L.M.); Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, “Titu Maiorescu” University, 031593 Bucharest, Romania 
 Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania; [email protected] (M.S.); [email protected] (A.M.); [email protected] (C.C.) 
 Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania; [email protected] (M.S.); [email protected] (A.M.); [email protected] (C.C.); Faculty of Biology, University of Bucharest, 030018 Bucharest, Romania 
 Department of Dermatology, The “Carol Davila” Central Military Emergency Hospital, 010825 Bucharest, Romania; [email protected] 
 Biochemistry Laboratory, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania; [email protected]; Faculty of Medicine, “Titu Maiorescu” University, 031593 Bucharest, Romania 
 Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania; [email protected] (M.S.); [email protected] (A.M.); [email protected] (C.C.); Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania 
 Department of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; [email protected] 
 Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania; [email protected] (M.S.); [email protected] (A.M.); [email protected] (C.C.); Faculty of Biology, University of Bucharest, 030018 Bucharest, Romania; Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania 
 Department of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; [email protected]; Department of Dermatology, Prof. N.C. Paulescu National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania 
First page
342
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
22279032
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2632744662
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.