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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

In the last decade there has been tremendous effort in offering better therapeutic management strategies to patients with hematologic malignancies. These efforts have ranged from biological to clinical approaches and resulted in the rapid development of new approaches. The main “problem” that comes with the high influx of newly approved drugs, which not only influences hematologists that frequently work with these drugs but also affects other healthcare professionals that work with hematologists in patient management, including intensive care unit (ICU) physicians, is they have to keep up within their specialty and, in addition, with the side-effects that can occur when encountering hematology-specific therapies. Nonetheless, there are few people that have an in-depth understanding of a specialty outside theirs. Thus, this manuscript offers an overview of the most common side-effects caused by therapies used in hematology nowadays, or that are currently being investigated in clinical trials, with the purpose to serve as an aid to other specialties. Nevertheless, because of the high amount of information on this subject, each chapter will offer an overview of the side-effects of a drug class with each reference of the section being intended as further reading.

Details

Title
Overview of the Side-Effects of FDA- and/or EMA-Approved Targeted Therapies for the Treatment of Hematological Malignancies
Author
Constantinescu, Catalin 1   VIAFID ORCID Logo  ; Pasca, Sergiu 2 ; Alina-Andreea Zimta 3   VIAFID ORCID Logo  ; Tat, Tiberiu 4 ; Rus, Ioana 5 ; Teodorescu, Patric 6   VIAFID ORCID Logo  ; Iluta, Sabina 6 ; Tanase, Alina 7   VIAFID ORCID Logo  ; Colita, Anca 7 ; Sigurjonsson, Olafur 8   VIAFID ORCID Logo  ; Einsele, Hermann 9 ; Tomuleasa, Ciprian 10   VIAFID ORCID Logo 

 Intensive Care Unit, Ion Chiricuta Clinical Cancer Center, 400010 Cluj Napoca, Romania; [email protected] (C.C.); [email protected] (T.T.); Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400004 Cluj Napoca, Romania; [email protected] (S.P.); [email protected] (P.T.); [email protected] (S.I.); Department of Anesthesia and Intensive Care, Iuliu Hatieganu University of Medicine and Pharmacy, 400000 Cluj Napoca, Romania 
 Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400004 Cluj Napoca, Romania; [email protected] (S.P.); [email protected] (P.T.); [email protected] (S.I.); Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400000 Cluj Napoca, Romania; [email protected] 
 Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400000 Cluj Napoca, Romania; [email protected] 
 Intensive Care Unit, Ion Chiricuta Clinical Cancer Center, 400010 Cluj Napoca, Romania; [email protected] (C.C.); [email protected] (T.T.) 
 Department of Hematology, Ion Chiricuta Clinical Cancer Center, 400014 Cluj Napoca, Romania; [email protected] 
 Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400004 Cluj Napoca, Romania; [email protected] (S.P.); [email protected] (P.T.); [email protected] (S.I.); Department of Hematology, Ion Chiricuta Clinical Cancer Center, 400014 Cluj Napoca, Romania; [email protected] 
 Department of Stem Cell Transplantation, Fundeni Clinical Institute, 925200 Bucharest, Romania; [email protected] (A.T.); [email protected] (A.C.) 
 The Blood Bank, Landspitali–the National University Hospital of Iceland, Snorrabraut 60, 101 Reykjavik, Iceland; [email protected] 
 Department of Internal Medicine II, University Hospital Würzburg, 97080 Würzburg, Germany; [email protected] 
10  Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400004 Cluj Napoca, Romania; [email protected] (S.P.); [email protected] (P.T.); [email protected] (S.I.); Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400000 Cluj Napoca, Romania; [email protected]; Department of Hematology, Ion Chiricuta Clinical Cancer Center, 400014 Cluj Napoca, Romania; [email protected] 
First page
2903
Publication year
2020
Publication date
2020
Publisher
MDPI AG
e-ISSN
20770383
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2641062669
Copyright
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.