Content area
Abstract
Most of the published works so far have aimed at finding genes associated with multiple sclerosis (MS) susceptibility. Very few studies have attempted to correlate disease features with DNA variants. In a well-characterized sample (651 patients) representative of multiple sclerosis natural history, we engaged a comprehensive study of the role of human leukocyte antigen (HLA) in the course of the disease. We investigated the role of HLA-DRB1*15 allele in samples stratified according to severity evaluated by the Multiple Sclerosis Severity Score (MSSS), time to reach EDSS 6.0 and disease type. We found that HLA-DRB1*15 genotype does not influence MS severity even among patients presenting with a given type of the disease. However, we show for the first time that HLA-DRB1*15 allele modulates the course of MS for relapsing–remitting (RR) onset patients likely by precipitating the secondary progressive (SP) phase.
Details
1 INSERM, UMRS 546, Paris, France (GRID:grid.7429.8) (ISNI:0000000121866389); Université Pierre et Marie Curie-Paris 6, Paris, France (GRID:grid.462844.8) (ISNI:0000 0001 2308 1657); Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, France (GRID:grid.411439.a) (ISNI:0000 0001 2150 9058)
2 INSERM, UMRS 535, Villejuif, France (GRID:grid.457369.a); Université Paris Sud, Villejuif, France (GRID:grid.5842.b) (ISNI:0000 0001 2171 2558)
3 CHU Pontchaillou, Département de santé publique et d'épidémiologie, Rennes, France (GRID:grid.414271.5); CHU Pontchaillou, Département de neurologie, Rennes, France (GRID:grid.414271.5)
4 INSERM, UMRS 546, Paris, France (GRID:grid.7429.8) (ISNI:0000000121866389); Université Pierre et Marie Curie-Paris 6, Paris, France (GRID:grid.462844.8) (ISNI:0000 0001 2308 1657)
5 Université de Rennes 1, Rennes, France (GRID:grid.410368.8) (ISNI:0000 0001 2191 9284)
6 Pôle des Neurosciences, INSERM, UMR 563, Université Paul Sabatier, Toulouse III, Toulouse, France (GRID:grid.15781.3a) (ISNI:0000 0001 0723 035X)
7 CHU Pontchaillou, Département de neurologie, Rennes, France (GRID:grid.414271.5)
8 Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-salpêtrière, Département de Santé publique, Paris, France (GRID:grid.411439.a) (ISNI:0000 0001 2150 9058)