Abstract
[...]we propose that it is possible to identify drugs potentially regulative for BCa, based on a newly established algorithm predicting the infiltration level of immune and stromal cells in the tumor microenvironment. [...]these results enhance the idea that HIF-1α may be a potential target of immunotherapy for BCa. Caspase-8 plays an essential role by regulating the immune response, B and T lymphocyte activation, and macrophage differentiation and polarization. [...]caspase-8 is an important regulator of immune cell homeostasis and cytokine production, which are the two major components of the tumor microenvironment. [...]the current study identified six potentially regulative drugs (FG-2216, Emricasan, ENMD-1198, Carvedilol, PX-478, and 2-Methoxyestradiol) and a potential immunotherapy target (EFNB2) of BCa based on the concept of the tumor microenvironment.
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1 Department of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China; Institute of System Genetics, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
2 West China Biomedical Big Data Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
3 Department of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
4 Department of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
5 West China Medical School of Sichuan University, Chengdu, Sichuan 610041, China
6 Institute of System Genetics, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China