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Abstract
The purpose of this study was to test the toxicity of a Siddha drug, Sivanar Vembu Khuzhi Thailam (SVKT), in Sprague Dawley rats. The chronic toxicity study was conducted in accordance with (OECD) test guideline 408. In this study, SVKT was administered orally every day to groups 1 to 3 of rats at doses of 40, 130, and 400 mg/kg body weight for a period of 90 days. An additional satellite group (group 4) received 400 mg/kg body weight of SVKT for 90 days and did not receive the drug for another 28 days. The experiment ended on day 118 for the group 4 and day 90 for the other groups. The animals' body weight was measured once a month. Hematological and biochemical analyses were performed at the conclusion of the experiment. Histopathological examination of vital organs of rats was performed for gross findings. Organ weights were also recorded.
There was no significant difference (p > 0.05) observed in the relative organs weight, body weight. However, histopathological findings seen in test groups were also seen in control. The increase in total WBC and differential counts were within normal physiological range.
Experimental article (J Int Dent Med Res 2022; 15(1): 88-93)
Keywords: Siddha, Sivanar Vembu Khuzhi Thailam, chronic toxicity study.
I Received date: 11 December 2021 Accept date: 14 January 2022 |
Introduction
Medicinal plants are a storehouse of various bioactive chemicals with different medicinal qualities. According to a survey conducted by the World Health Organization, traditional herbal formulations are popular among 80 percent of the population in underdeveloped countries to treat ailments1. Many natural elements found in plants, such as polyphenols, flavonoids, and tannins, are protective and curative in various ways2. Siddha is a traditional medical system that dates back thousands of years. This system of medicine is used to address acute and chronic medical problems and is primarily practiced in the southern part of India3. Standardization of herbal formulations is vital in determining the quality of the drug based on the concentration of its active principle and assuring its safety profile, of which botanicals are an essential part of this type of traditional medicine4. Before beginning a human trial, preclinical toxicity research is essential to define a safe dose and find the...