Commentary to: Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality

Abstract

In the context of critically ill patients, mostly observational studies have addressed mortality risk in patients managed under hyperoxemia—defined differently as partial arterial pressure of oxygen (PaO2) greater than 100 mmHg to 487 mmHg—finding a higher mortality risk in these patients [2]. Noteworthy, there is a published thesis associated with the same ethics approval number (PI 20–2070), reporting the same number of patients, but with important differences in selection criteria since there is no mention of patients having met 48 h with the same PaO2 and septic shock with a negative culture is not mentioned as an exclusion criteria [8]. [...]we requested the dataset from the authors to perform re-analyses and verify these points.