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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Viral infections represent a major health problem worldwide. Due to the wide variety of etiological agents and their increasing resistance to anti-virals and antibiotics treatments, new strategies for effective therapies need to be developed. Scientific evidence suggests that probiotics may have prophylactic and therapeutic effects in viral diseases. Indeed, these microorganisms interact harmoniously with the intestinal microbiota and protect the integrity of the intestinal barrier as well as modulate the host immune system. Currently, clinical trials with probiotics have been documented in respiratory tract infections, infections caused by human immunodeficiency viruses, herpes, human papillomavirus and hepatic encephalopathy. However, the benefits documented so far are difficult to extrapolate, due to the strain-dependent effect. In addition, the dose of the microorganism used as well as host characteristics are other parameters that should be consider when advocating the use of probiotics to treat viral infections. This review addresses the scientific evidence of the efficacy of probiotics in clinical strains perspective in viral infectious diseases in the last 10 years.

Details

Title
Probiotics against Viral Infections: Current Clinical Trials and Future Perspectives
Author
Reyes-Castillo, Pedro A 1   VIAFID ORCID Logo  ; González-Vázquez, Raquel 2 ; Torres-Maravilla, Edgar 3   VIAFID ORCID Logo  ; Tello, Mario 4   VIAFID ORCID Logo  ; Bermúdez-Humarán, Luis G 3   VIAFID ORCID Logo  ; Mayorga-Reyes, Lino 5 

 Laboratorio de Biotecnologia, Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Xochimilco, Mexico 04960, Mexico; [email protected] 
 Laboratorio de Biotecnología, Departamento de Sistemas Biológicos, CONACYT-Universidad Autónoma Metropolitana Xochimilco, Mexico 04960, Mexico 
 INRAE, AgroParisTech, Micalis Institute, Université Paris-Saclay, 78350 Jouy-en-Josas, France; [email protected] 
 Laboratorio de Metagenomica Bacteriana, Centro de Biotecnología Acuícola, Departamento de Biología, Universidad de Santiago, Alameda 3363, Estación Central, Santiago 9170002, Chile; [email protected]; Ictio Biotechnologies S.A., General del Canto, Santiago 7500000, Chile 
 Laboratorio de Biotecnología, Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana Xochimilco, Mexico 04960, Mexico; [email protected] 
First page
468
Publication year
2021
Publication date
2021
Publisher
MDPI AG
ISSN
26735601
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2656391534
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.