Full Text

Turn on search term navigation

HIGHLIGHTS

  • MPPD was used to estimate lung deposition of welding fume PM2.5.
  • Overall incidence rate of COPD in shipyard workers was 2.51 cases per 100 person-years.
  • An increase in welding fume PM2.5 was associated with lung function declines.
  • Increase in PM2.5 deposition in lung regions associated with lung function declines.

    • View Image - Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort StudyEnlarge this image.

    Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study

    AuthorAffiliation

    Nguyen Thanh Tung1,2, Ching-Huang Lai3, Chih-Hong Pan3,4, Wei-Liang Chen5,6,7, Chung-Ching Wang5,6,7, Che-Wei Liang3, Chi-Yu Chien3, Kai-Jen Chuang8,9, Huynh Nguyen Xuan Thao10, Hoang Ba Dung2, Tran Phan Chung Thuy11, Hsiao-Chi Chuang 12,13,14

    1 International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    2 Otorhinolaryngology Department, Cho Ray Hospital, Ho Chi Minh City, Vietnam

    3 School of Public Health, National Defense Medical Center, Taipei, Taiwan

    4 Institute of Labor, Occupational Safety and Health, Ministry of Labor, New Taipei City, Taiwan

    5 Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, Taipei, Taiwan

    6 Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, Taipei, Taiwan

    7 School of Medicine, National Defense Medical Center, Taipei, Taiwan

    8 School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan

    9 Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    10 Otorhinolaryngology Department, Ho Chi Minh City University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam

    11 Otorhinolaryngology Department, Faculty of Medicine, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam

    12 School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan

    13 Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

    14 Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan

    Word count: 287

    Show less

    © 2022. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

    Abstract

    The association between lung deposition of particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5) from welding fumes and lung function is unclear. We conducted a cohort study with a follow-up of 4 years in 115 shipyard workers to investigate the incidence rate of chronic obstructive pulmonary disease (COPD), and to evaluate the effects of welding fume PM2.5 deposition on fractional exhaled nitric oxide (FeNO), lung function, and blood pressure using generalized estimating equation models. Personal exposure to welding fumes was measured, and deposition fractions of inhaled welding fume PM2.5 in lung regions were estimated using multiple-path particle dosimetry. We observed the overall incidence rate of COPD to be 2.51 cases per 100 person-years. The incidence rate was higher in welding workers than in office workers and higher in non-smokers compared to smokers. In the overall cohort subjects, we observed that an increase in the interquartile range of PM2.5 was associated with a 1.618-ppb decrease in FeNO, a 0.115-L decrease in FVC, a 0.091-L decrease in FEV1, a 0.520% increase in the FEV1/FVC ratio, a 0.259-L s–1 decrease in PEF, a 0.096-L s–1 decrease in FEF25%-75%, a 0.215-L s–1 decrease in FEF25%, and a 0.114-L s–1 decrease in FEF50% (all p < 0.05). We observed that a 1-µg m–3 increase in PM2.5 deposition in lung regions (total lung, and head and nasal, tracheobronchial, and alveolar regions) was associated with decreases (β coefficients) in FeNO, FVC, FEV1, PEF, FEF25%-75%, FEF25%, and FEF50% (all p < 0.05). We observed that the absolute values of β coefficients decreased as follows: alveolar > head and nasal > tracheobronchial > total lung regions. Higher incidence rates of COPD were observed in non-smokers and welders, which associated with lung function declines due to PM2.5 exposure. Pulmonary effects by welding fume PM2.5 in occupational settings is an urgent occupational issue for worker health protection.

    Details

    Title
    Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study
    Author
    Nguyen Thanh Tung; Ching-Huang, Lai; Chih-Hong, Pan; Wei-Liang, Chen; Chung-Ching, Wang; Che-Wei, Liang; Chi-Yu, Chien; Kai-Jen Chuang; Huynh Nguyen Xuan Thao; Hoang Ba Dung; Tran Phan Chung Thuy; Hsiao-Chi Chuang  VIAFID ORCID Logo 
    Publication year
    2022
    Publication date
    May 2022
    Publisher
    Taiwan Association of Aerosol Research
    ISSN
    16808584
    e-ISSN
    20711409
    Source type
    Scholarly Journal
    Language of publication
    English
    DOI
    https://doi.org/10.4209/aaqr.210272
    ProQuest document ID
    2657868536
    Copyright
    © 2022. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.