Abstract

Unmanageable bleeding is one of the significant causes of mortality. Attaining rapid hemostasis ensures subject survivability as a first aid during combats, road accidents, surgeries that reduce mortality. Nanoporous fibers reinforced composite scaffold (NFRCS) developed by a simple hemostatic film-forming composition (HFFC) (as a continuous phase) can trigger and intensify hemostasis. NFRCS developed was based on the dragonfly wing structure's structural design. Dragonfly wing structure consists of cross-veins and longitudinal wing veins inter-connected with wing membrane to maintain the microstructural integrity. The HFFC uniformly surface coats the fibers with nano thickness film and interconnects the randomly distributed cotton gauge (Ct) (dispersed phase), resulting in the formation of a nanoporous structure. Integrating continuous and dispersed phases reduce the product cost by ten times that of marketed products. The modified NFRCS (tampon or wrist band) can be used for various biomedical applications. The in vivo studies conclude that the developed Cp NFRCS triggers and intensifies the coagulation process at the application site. The NFRCS could regulate the microenvironment and act at the cellular level due to its nanoporous structure, which resulted in better wound healing in the excision wound model.

Details

Title
Nanoporous and nano thickness film-forming bioactive composition for biomedical applications
Author
Chevala Naga Thirumalesh 1 ; Kumar, Lalit 1 ; Veetilvalappil Vimal 2 ; Mathew Aranjani Jesil 2 ; Bemma, Paonam 3 ; Mohan, Ganesh 3 ; Shastry Shamee 3 ; Balasubramanian Krishnan 4 ; Mallikarjuna, Rao C 5 

 Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Department of Pharmaceutics, Manipal, India (GRID:grid.411639.8) (ISNI:0000 0001 0571 5193) 
 Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Department of Biotechnology, Manipal, India (GRID:grid.411639.8) (ISNI:0000 0001 0571 5193) 
 Kasturba Medical College, Manipal Academy of Higher Education, Department of Immunohematology and Blood Transfusion, Manipal, India (GRID:grid.411639.8) 
 Indian Institute of Technology, Department of Mechanical Engineering, Madras, India (GRID:grid.417969.4) (ISNI:0000 0001 2315 1926) 
 Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Department of Pharmacology, Manipal, India (GRID:grid.411639.8) (ISNI:0000 0001 0571 5193) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2665414157
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.