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Abstract
Routine clinical use of absolute PET quantification techniques is limited by the need for serial arterial blood sampling for input function and more importantly by the lack of automated pharmacokinetic analysis tools that can be readily implemented in clinic with minimal effort. PET/MRI provides the ability for absolute quantification of PET probes without the need for serial arterial blood sampling using image-derived input functions (IDIFs). Here we introduce caliPER, a modular and scalable software for simplified pharmacokinetic modeling of PET probes with irreversible uptake or binding based on PET/MR IDIFs and Patlak Plot analysis. caliPER generates regional values or parametric maps of net influx rate (K
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; St Lawrence, Keith S 1 ; Moran, Gerald 9 ; Anazodo, Udunna C 10
1 Lawson Health Research Institute, London, Ontario, Canada; Department of Medical Biophysics, Western University, London, Ontario, Canada
2 Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, Canada; Siemens Healthineers, Oakville, Mississauga, Ontario, Canada
3 Lawson Health Research Institute, London, Ontario, Canada; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
4 Department of Medical Biophysics, Western University, London, Ontario, Canada
5 Lawson Health Research Institute, London, Ontario, Canada
6 Department of Physics and Astronomy, Western University, London, Ontario, Canada
7 Siemens Healthcare GmbH, Healthineers, Erlangen, Germany
8 Siemens Medical Solutions USA, Inc., Hoffman Estates, IL, USA
9 Siemens Healthineers, Oakville, Mississauga, Ontario, Canada
10 Lawson Health Research Institute, London, Ontario, Canada; Department of Medical Biophysics, Western University, London, Ontario, Canada; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada