Abstract

Background

Gestational diabetes mellitus is the most common metabolic dysfunction that arises during pregnancy. GDM can lead to serious health complications for both the mother during pregnancy and after the delivery of the baby. Additionally, mother–offspring suffers from abnormalities in metabolism. The study aimed to investigate glutathione S‑transferase P1 and ghrelin genetic variants in pregnant women diagnosed with gestational diabetes using a tetra-primer amplification refractory mutation system.

Results

This study demonstrated that the frequencies of genotypes in women with GDM were GSTP1-AG (87.1%) and GHRL-GG (100%). The study revealed no significant differences in the frequency of either genotype or allele of both GSTP1 and ghrelin between GDM and healthy pregnant women.

Conclusions

This study may be the first study designed to demonstrate that there is no association between the genotype and allele frequencies of GSTP1 (rs1695) and ghrelin (rs696217) in the development of gestational diabetes mellitus in Egyptian women.

Details

Title
Impact of gene polymorphism of glutathione S-transferase and ghrelin as a risk factor in Egyptian women with gestational diabetes mellitus
Author
Madkour, Mai M. 1 ; El-Said, Afaf M. 2 ; El-Refaey, Abd El-Aziz A. 3 ; Abd El-Aziz, Abd El-Aziz F. 1 ; El-Senduny, Fardous F. 1   VIAFID ORCID Logo 

1  Mansoura University, Biochemistry Division, Department of Chemistry, Faculty of Science, Mansoura, Egypt (GRID:grid.10251.37) (ISNI:0000000103426662) 
2  Mansoura University, Genetic Unit, Department of Pediatrics, Faculty of Medicine, Mansoura, Egypt (GRID:grid.10251.37) (ISNI:0000000103426662) 
3  Mansoura University, Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura, Egypt (GRID:grid.10251.37) (ISNI:0000000103426662) 
Pages
15
Publication year
2022
Publication date
Dec 2022
Publisher
Springer Nature B.V.
ISSN
11108630
e-ISSN
20902441
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s43042-022-00228-6
ProQuest document ID
2670525094
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.