Abstract
In a study on the Shank3 mutant mouse model, researchers found that Shank3 mutant mice exhibited stereotyped behavior like ASD and damaged social interactions. When Shank3 gene was re-expressed, the protein synthesis returned to normal, the synaptic structure was restored, the synaptic function was improved, and stereotyped behavior like ASD were also corrected. Among them, eIF-4G is a multi-domain adaptor protein, responsible for binding eIF-4E, eIF-3, and poly-A tail binding protein PAB; eIF-4E is responsible for binding the 5′-end cap structure of mRNA; eIF-4A has activity of RNA helicase, which can remove the hairpin structure at the 5′-end of the mRNA and bind it to the small ribosomal subunit. In the study of eIF-4E transgenic mice, researchers found that eIF-4E levels in eIF-4E transgenic mice increased, the eIF-4E/eIF-4G interaction level was significantly enhanced, the control of protein translation is dysfunctional, and the mice exhibit abnormal behavior consistent with ASD.
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Details
1 Department of Child Healthcare Center, Fujian Provincial Maternal and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350000, China; School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian 350004, China
2 Department of Child Healthcare Center, Fujian Provincial Maternal and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350000, China
3 Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China