Abstract

With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged from twenty-six neonatal intensive care units in Guangdong Province of China during 2008–2017 were analyzed. A total of 2575 ELBW infants were enrolled and the overall survival rate was 55.11%. From 2008 to 2017, the number of ELBW infants increased rapidly from 91 to 466, and the survival rate improved steadily from 41.76% to 62.02%. Increased survival is closely related to birth weight (BW), regional economic development, and specialized hospital. The incidence of complications was neonatal respiratory distress syndrome (85.2%), oxygen dependency at 28 days (63.7%), retinopathy of prematurity (39.3%), intraventricular hemorrhage (29.4%), necrotizing enterocolitis (12.0%), and periventricular leukomalacia (8.0%). Among the 1156 nonsurvivors, 90.0% of infants died during the neonatal period (≤ 28 days). A total of 768 ELBW infants died after treatment withdrawal, for reasons of economic and/or poor outcome. The number of ELBW infants is increasing in Guangdong Province of China, and the overall survival rate is improving steadily.

Details

Title
Short term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China
Author
Jia, Chun-Hong 1 ; Feng, Zhou-Shan 2 ; Lin, Xiao-Jun 2 ; Cui, Qi-Liang 2 ; Han, Sha-Sha 3 ; Jin, Ya 3 ; Liu, Guo-Sheng 3 ; Yang, Chuan-Zhong 4 ; Ye, Xiao-Tong 4 ; Dai, Yi-Heng 5 ; Liang, Wei-Yi 5 ; Ye, Xiu-Zhen 6 ; Mo, Jing 6 ; Ding, Lu 7 ; Wu, Ben-Qing 7 ; Chen, Hong-Xiang 8 ; Li, Chi-Wang 8 ; Zhang, Zhe 9 ; Rong, Xiao 9 ; Huang, Wei-Min 10 ; Shen, Wei 10 ; Yang, Bing-Yan 11 ; Lv, Jun-Feng 11 ; Huo, Le-Ying 12 ; Huang, Hui-Wen 12 ; Rao, Hong-Ping 13 ; Yan, Wen-Kang 13 ; Yang, Yong 14 ; Ren, Xue-Jun 14 ; Liu, Dong 15 ; Wang, Fang-Fang 15 ; Diao, Shi-Guang 16 ; Liu, Xiao-Yan 16 ; You, Chu-Ming 17 ; Meng, Qiong 17 ; Wang, Bin 18 ; Zhang, Li-Juan 18 ; Huang, Yu-Ge 19 ; Ao, Dang 19 ; Li, Wei-Zhong 20 ; Chen, Jie-Ling 20 ; Chen, Yan-Ling 21 ; Li, Wei 21 ; Chen, Zhi-Feng 22 ; Ding, Yue-Qin 22 ; Li, Xiao-Yu 23 ; Huang, Yue-Fang 23 ; Lin, Ni-Yang 24 ; Cai, Yang-Fan 24 ; Wan, Zhong-He 25 ; Ban, Yi 25 ; Bai, Bo 26 ; Li, Guang-Hong 26 ; Yan, Yue-Xiu 27 ; Wu, Fan 1 

 The Third Affiliated Hospital of Guangzhou Medical University, Department of Pediatrics, Guangzhou, China (GRID:grid.417009.b) (ISNI:0000 0004 1758 4591); Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, China (GRID:grid.484195.5) 
 The Third Affiliated Hospital of Guangzhou Medical University, Department of Pediatrics, Guangzhou, China (GRID:grid.417009.b) (ISNI:0000 0004 1758 4591) 
 The First Affiliated Hospital of Jinan University, Department of Neonatology, Guangzhou, China (GRID:grid.412601.0) (ISNI:0000 0004 1760 3828) 
 Affiliated Southern Medical University, Department of Neonatology, Shenzhen Maternal and Child Healthcare Hospital, Shenzhen, China (GRID:grid.284723.8) (ISNI:0000 0000 8877 7471) 
 Foshan Maternal and Child’s Hospital, Department of Neonatology, Foshan, China (GRID:grid.284723.8) 
 Women and Children Hospital of Guangdong Province, Department of Neonatology, Guangzhou, China (GRID:grid.284723.8) 
 Shenzhen People’s Hospital, Department of Neonatology, Shenzhen, China (GRID:grid.440218.b) (ISNI:0000 0004 1759 7210) 
 Meizhou People’s Hospital, Department of Neonatology, Meizhou, China (GRID:grid.459766.f) 
 Guangzhou Women and Children’s Medical Center, Department of Neonatology, Guangzhou, China (GRID:grid.413428.8) (ISNI:0000 0004 1757 8466) 
10  Nanfang Hospital of Southern Medical University, Department of Neonatology, Guangzhou, China (GRID:grid.416466.7) (ISNI:0000 0004 1757 959X) 
11  Boai Hospital of Zhongshan, Department of Neonatology, Zhongshan, China (GRID:grid.460171.5) (ISNI:0000 0004 9332 4548) 
12  Zhuhai Maternity and Child Health Hospital, Department of Neonatology, Zhuhai, China (GRID:grid.460171.5) 
13  Huizhou Municipal Central Hospital, Department of Neonatology, Huizhou, China (GRID:grid.470066.3) 
14  Dongguan Maternity and Child Health Hospital, Department of Neonatology, Dongguan, China (GRID:grid.470066.3) 
15  Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University, Department of Neonatology, Jiangmen, China (GRID:grid.459671.8) (ISNI:0000 0004 1804 5346) 
16  Yuebei People’s Hospital, Department of Neonatology, Shaoguan, China (GRID:grid.478147.9) (ISNI:0000 0004 1757 7527) 
17  Guangdong Second Provincial People’s Hospital, Department of Neonatology, Guangzhou, China (GRID:grid.478147.9) 
18  Zhujiang Hospital of Southern Medical University, Department of Pediatrics, Guangzhou, China (GRID:grid.417404.2) (ISNI:0000 0004 1771 3058) 
19  The Affiliated Hospital of Guangdong Medical University, Department of Pediatrics, Zhanjiang, China (GRID:grid.410560.6) (ISNI:0000 0004 1760 3078) 
20  The Second Affiliated Hospital of Shantou University Medical College, Department of Neonatology, Shantou, China (GRID:grid.452836.e) (ISNI:0000 0004 1798 1271) 
21  Jinan University Medical College Affiliated Dongguan Hospital, Department of Neonatology, Dongguan, China (GRID:grid.258164.c) (ISNI:0000 0004 1790 3548) 
22  Dongguan People’s Hospital, Department of Pediatrics, Dongguan, China (GRID:grid.440180.9) (ISNI:0000 0004 7480 2233) 
23  The First Affiliated Hospital of Sun Yat-Sen University, Department of Neonatology, Guangzhou, China (GRID:grid.412615.5) (ISNI:0000 0004 1803 6239) 
24  The First Affiliated Hospital of Shantou University Medical College, Department of Neonatology, Shantou, China (GRID:grid.412614.4) (ISNI:0000 0004 6020 6107) 
25  Nanhai District People’s Hospital of Foshan, Department of Neonatology, Foshan, China (GRID:grid.412614.4) 
26  Huadu District People’s Hospital of Guangzhou, Department of Neonatology, Guangzhou, China (GRID:grid.412614.4) 
27  The First People’s Hospital of Zhaoqing, Department of Pediatrics, Zhaoqing, China (GRID:grid.502971.8) (ISNI:0000 0004 1758 1569) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2683055664
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.