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Contents
- Abstract
- Running Example: The JOBS II Study
- The Potential Outcomes Framework for Causal Mediation Analysis
- Bayesian Additive Regression Trees
- A General Introduction to Bayesian Additive Regression Trees
- BART Models for Yi and Mi in Mediation (BCMFs)
- Special Considerations for Causal Mediation Analysis
- Prior Dogmatism
- Inclusion of Clever Covariates in BART
- Stratification on A
- Model for the Covariates
- Computation of the Mediation Effects From BART Models
- Simulation Study
- Methods for Comparison
- LSEM
- Naive BART
- BART With Clever Covariates
- Stratified BART With Clever Covariates
- TMLE
- Simulation Settings
- Nonlinear, No Direct Effect (No-Direct)
- Nonlinear, No Indirect Effect (No-Indirect)
- Linear With Treatment-Mediator Interaction
- Criteria for Comparison
- Results for Nonlinear Settings
- Bias and RMSE
- Coverage and Interval Width
- Machine Learning With Smaller Sample Sizes
- Results for Linear Model
- The Effect of Unmeasured Confounding
- Theorem 1
- A Sensitivity Analysis Framework
- Illustration on JOBS II Dataset
- Analysis Under Sequential Ignorability
- Sensitivity Analysis
- Discussion
- Extensions
- On Stratification of the Treatment A
- Causal Mediation With Nonbinary A and/or Multiple Mediators
- Quantile Causal Mediation Effects
- What If the Treatment Is Not Randomized?
- Concluding Remarks
- Appendix A
- Appendix B
Figures and Tables
Abstract
We present a general framework for causal mediation analysis using nonparametric Bayesian methods in the potential outcomes framework. Our model, which we refer to as the Bayesian causal mediation forests model, combines recent advances in Bayesian machine learning using decision tree ensembles, Bayesian nonparametric causal inference, and a Bayesian implementation of the g-formula for computing causal effects. Because of its strong performance on simulated data and because it greatly reduces researcher degrees of freedom, we argue that Bayesian causal mediation forests are highly attractive as a default approach. Of independent interest, we also introduce a new sensitivity analysis technique for mediation analysis with continuous outcomes that is widely applicable. We demonstrate our approach on both simulated and real data sets, and show that our approach obtains low mean squared error and close to nominal coverage of 95% interval estimates, even in highly nonlinear problems on which other methods fail.
Many problems of psychological interest, the effect of some intervention on a given individual may be...





