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Abstract
[...]several reports from the first COVID-19 wave in spring 2020 showed a significant decrease in new cancer diagnoses as well as cancer therapy and screenings [ 5, 6]. (A) according to age and gender; (B) according to cancer location; (C) relative changes per month; (D) relative and absolute change of incidence of benign, pre-malignant and malignant lesions according to organ screening program.Abbreviations: IH – Insurance holders; MN – malignant neoplasm; CNS – central nervous system When analyzing entity-specific changes, a clear difference in the decrease of diagnoses which ranged from a non-significant decrease of 5.77% (95%CI: -0.03[0.03 to -0.09] per 10,000 IH; not significant) for brain and eye tumors (C69-C72) to a decrease of more than 30% for breast cancer (-1.35[95%CI: -1.21 to -1.5] per 10,000 IH; P < 0.001) and for melanoma (-1.06[95%CI: -0.94 to -1.19] per 10,000 IH; P < 0.001) was found (Figure 1B; Supplementary Table S4). [...]due to our study's retrospective nature, no direct causal inference between the COVID-19 pandemic and the decrease in newly diagnosed cancerous and precancerous lesions could be made. [...]besides the direct impact of COVID 19 on health, there seems to be major collateral damage associated with the under-diagnosis of other medical conditions.
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Details
1 Department of General, Visceral, Transplantation, Vascular and Pediatric Surgery, University Hospital, University of Wuerzburg, Wuerzburg, Germany
2 Department Medizin und Versorgungsforschung, Institut fuer Gesundheitssystemforschung, Barmer, Wuppertal, Germany
3 Department of General, Visceral, Transplantation, Vascular and Pediatric Surgery, University Hospital, University of Wuerzburg, Wuerzburg, Germany; Department of Biochemistry and Molecular Biology, University of Wuerzburg, Wuerzburg, Germany
4 Department of General, Visceral, Transplantation, Vascular and Pediatric Surgery, University Hospital, University of Wuerzburg, Wuerzburg, Germany; Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Centre, Wuerzburg, Germany
5 Department of General, Visceral, Transplantation, Vascular and Pediatric Surgery, University Hospital, University of Wuerzburg, Wuerzburg, Germany; Department of Biochemistry and Molecular Biology, University of Wuerzburg, Wuerzburg, Germany; Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Centre, Wuerzburg, Germany