Abstract

Cardiac microvascular obstruction (MVO) associated with acute myocardial infarction (heart attack) is characterized by partial or complete elimination of perfusion in the myocardial microcirculation. A new catheter-based method (CoFI, Controlled Flow Infusion) has recently been developed to diagnose MVO in the catheterization laboratory during acute therapy of the heart attack. A porcine MVO model demonstrates that CoFI can accurately identify the increased hydraulic resistance of the affected microvascular bed. A benchtop microcirculation model was developed and tuned to reproduce in vivo MVO characteristics. The tuned benchtop model was then used to systematically study the effect of different levels of collateral flow. These experiments showed that measurements obtained in the catheter-based method were adversely affected such that collateral flow may be misinterpreted as MVO. Based on further analysis of the measured data, concepts to mitigate the adverse effects were formulated which allow discrimination between collateral flow and MVO.

Details

Title
Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction
Author
Thirugnanasambandam, Mirunalini 1 ; Frey, Sabrina 2 ; Rösch, Yannick 1 ; Mantegazza, Alberto 3 ; Clavica, Francesco 1 ; Schwartz, Robert S. 4 ; Cesarovic, Nikola 5 ; Obrist, Dominik 1   VIAFID ORCID Logo 

1  University of Bern, ARTORG Center for Biomedical Engineering Research, Bern, Switzerland (GRID:grid.5734.5) (ISNI:0000 0001 0726 5157) 
2  University of Bern, ARTORG Center for Biomedical Engineering Research, Bern, Switzerland (GRID:grid.5734.5) (ISNI:0000 0001 0726 5157); CorFlow Therapeutics AG, Baar, Switzerland (GRID:grid.5734.5) 
3  University of Bern, ARTORG Center for Biomedical Engineering Research, Bern, Switzerland (GRID:grid.5734.5) (ISNI:0000 0001 0726 5157); Pennsylvania State University, Department of Biomedical Engineering, University Park, USA (GRID:grid.29857.31) (ISNI:0000 0001 2097 4281) 
4  CorFlow Therapeutics AG, Baar, Switzerland (GRID:grid.5734.5) 
5  ETH Zurich, Department of Health Science and Technology, Zurich, Switzerland (GRID:grid.5801.c) (ISNI:0000 0001 2156 2780); German Heart Center Berlin, Cardiosurgical Research Group, Department of Cardiothoracic and Vascular Surgery, Berlin, Germany (GRID:grid.418209.6) (ISNI:0000 0001 0000 0404) 
Pages
1090-1102
Publication year
2022
Publication date
Sep 2022
Publisher
Springer Nature B.V.
ISSN
00906964
e-ISSN
15739686
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s10439-022-02985-2
ProQuest document ID
2700161169
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.