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Abstract
Non-erosive reflux disease (NERD) is classified into grade N (no minimal change) and grade M (minimal change) based on the Los Angeles classification. However, few reports have described the clinical characteristics of grade M. This study was performed to clarify the clinical characteristics of grade M. Among 290 consecutive patients with gastroesophageal reflux disease (GERD), 45 patients with grade M, 62 patients with grade N, and 94 patients with grade A were compared with respect to clinical differences. The degree of symptom improvement after 4 weeks of proton pump inhibitor administration was also prospectively compared among the three groups. Grades N and M showed no or little difference in the patients’ backgrounds (including sex and body mass index), GERD/functional dyspepsia symptom scores, life dissatisfaction (diet, sleep, work, and mood), Short Form-8 (mental component summary) scores, and symptom improvement. In contrast, significant differences were present between grades M and A as well as between grades N and A. The overall results of our study suggest that the distinction between grade M and grade N is of little clinical significance from the viewpoint of clinical characteristics.
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Details
1 Kawasaki Medical School, Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Okayama, Japan (GRID:grid.415086.e) (ISNI:0000 0001 1014 2000)
2 Gamagori City Hospital, Gamagori City, Japan (GRID:grid.415086.e)
3 Osaka Medical and Pharmaceutical University, Second Department of Internal Medicine, Takatsuki, Japan (GRID:grid.415086.e)
4 Nippon Medical School Graduate School of Medicine, Department of Gastroenterology, Bunkyo-ku, Japan (GRID:grid.410821.e) (ISNI:0000 0001 2173 8328)
5 Nagoya City University Graduate School Medical Sciences, Department of Medical Innovation, Mizuho-ku, Japan (GRID:grid.260433.0) (ISNI:0000 0001 0728 1069)
6 Kawasaki Medical School, Department of General Internal Medicine 2, Kita-ku, Japan (GRID:grid.415086.e) (ISNI:0000 0001 1014 2000)
7 The Jikei University Daisan Hospital, Department of Laboratory Medicine, Komae City, Japan (GRID:grid.411898.d) (ISNI:0000 0001 0661 2073)