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Abstract
Dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that results in the phasic demineralization and remineralization of dental hard tissues. Caries can occur throughout life, both in primary and permanent dentitions, and can damage the tooth crown and, in later life, exposed root surfaces. The balance between pathological and protective factors influences the initiation and progression of caries. This interplay between factors underpins the classification of individuals and groups into caries risk categories, allowing an increasingly tailored approach to care. Dental caries is an unevenly distributed, preventable disease with considerable economic and quality-of-life burdens. The daily use of fluoride toothpaste is seen as the main reason for the overall decline of caries worldwide over recent decades. This Primer aims to provide a global overview of caries, acknowledging the historical era dominated by restoration of tooth decay by surgical means, but focuses on current, progressive and more holistic long-term, patient-centred, tooth-preserving preventive care.
The formation of dental caries involves the interaction between the tooth, the microbial biofilm at the tooth surface and dietary sugars. This Primer by Pitts et al. aims to provide a global overview of caries, focusing on current, patient-centred, tooth-preserving preventive care.
Details
1 Dental Innovation and Translation Centre, King's College London Dental Institute, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764)
2 Oral Health Research Institute, Indiana University School of Dentistry, Department of Cariology Operative Dentistry and Dental Public Health, Indianapolis, USA (GRID:grid.257413.6) (ISNI:0000 0001 2287 3919)
3 School of Dentistry, University of Leeds, Department of Oral Biology, Leeds, UK (GRID:grid.9909.9) (ISNI:0000 0004 1936 8403)
4 University of Copenhagen, Department of Odontology, Copenhagen, Denmark (GRID:grid.5254.6) (ISNI:0000 0001 0674 042X)
5 University of North Carolina School of Dentistry, Department of Dental Ecology, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000000122483208)
6 UCLA Center Children's Oral Health — UCCOH and Section of Pediatric Dentistry, UCLA School of Dentistry, University of California Los Angeles, Los Angeles, USA (GRID:grid.19006.3e) (ISNI:0000 0000 9632 6718)
7 Cariology and Operative Dentistry, Tokyo Medical and Dental University, Tokyo, Japan (GRID:grid.265073.5) (ISNI:0000 0001 1014 9130)
8 UCL, Department of Epidemiology and Public Health, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
9 Restorative Dentistry, Maurice H. Kornberg School of Dentistry, Temple University, Philadelphia, USA (GRID:grid.264727.2) (ISNI:0000 0001 2248 3398)




